Crizanlizumab

Introduction

Crizanlizumab is a monoclonal antibody medication used in the treatment of sickle cell disease. It is designed to reduce the frequency of pain crises (vaso-occlusive crises) in patients aged 16 years and above. Crizanlizumab helps improve quality of life by preventing the blockage of blood vessels caused by sickled red blood cells. The medication is administered via injection under medical supervision and is a significant advancement in managing sickle cell-related complications.

Uses of Crizanlizumab

• Treatment of sickle cell disease
• Reduction in frequency of vaso-occlusive crises (pain episodes)
• Prevention of blood vessel blockages caused by sickled cells

How Crizanlizumab Works

Crizanlizumab works by blocking a protein called P-selectin on the surface of blood cells and blood vessels. This action helps reduce the adhesion of sickled red blood cells to blood vessel walls, preventing the blockages that cause pain crises in sickle cell disease.

Benefits of Crizanlizumab

• Decreases the number of painful episodes in sickle cell patients
• Improves patient quality of life and mobility
• Reduces hospital visits and the need for pain management

How to Take Crizanlizumab

Crizanlizumab is given as an intravenous (IV) infusion by a healthcare professional. The recommended schedule includes an initial dose, a second dose two weeks later, and subsequent doses every four weeks. It should be taken exactly as prescribed by your doctor and under medical supervision.

Type of Dosage Available

• Intravenous infusion (Injection)

Side Effects of Crizanlizumab

• Common: Nausea, joint pain, back pain, fever
• Serious: Infusion-related reactions, allergic reactions, breathing difficulty
• Injection site reactions such as redness or swelling

Safety Advice

• Inform your doctor about any known allergies before starting
• Use with caution in pregnant or breastfeeding women
• Monitor for signs of infusion-related or allergic reactions
• Avoid missing scheduled infusions to ensure consistent benefits
• Keep out of reach of children and do not self-administer

Frequently Asked Questions (FAQs)

Q: What is Crizanlizumab used for?

A: Crizanlizumab is used to reduce the frequency of pain crises in patients with sickle cell disease.

Q: How is Crizanlizumab administered?

A: It is given as an intravenous infusion by a healthcare provider, usually once every four weeks after initial dosing.

Q: Can Crizanlizumab be used in children?

A: It is approved for patients aged 16 years and older. Consult your doctor for pediatric use.

Q: Are there any serious side effects?

A: Yes, though rare, serious side effects may include infusion reactions and allergic responses. Immediate medical help may be required.

Q: Where can I buy Crizanlizumab at a good price?

A: You can buy Crizanlizumab at the best price from Zeelab Pharmacy.