Estramustine

Introduction

Estramustine is a chemotherapy medication primarily used in the treatment of advanced prostate cancer. It combines two agents—estradiol (a form of estrogen) and nitrogen mustard (a cytotoxic compound). This combination helps slow the growth and spread of cancer cells in the prostate by interfering with cell division. Estramustine is usually prescribed when other hormonal therapies are not effective and is available in capsule form for oral use under medical supervision.

Uses of Estramustine

• Treatment of advanced prostate cancer
• Used when standard hormonal therapies fail
• Slows the progression of hormone-dependent tumors

How Estramustine Works

Estramustine works by combining estrogenic and cytotoxic properties. It inhibits the mitosis (cell division) of cancer cells by binding to microtubule-associated proteins and tubulin. This disrupts the cancer cell’s structure and function, leading to reduced tumor growth, especially in hormone-sensitive prostate cancer.

Benefits of Estramustine

• Helps control the growth of advanced prostate cancer
• Effective in patients unresponsive to other therapies
• Oral administration is convenient for long-term treatment
• Slows tumor progression by dual-action mechanism

How to Take Estramustine

Estramustine should be taken exactly as prescribed by your doctor. Usually, it is taken orally 3-4 times daily, at least 1 hour before or 2 hours after meals. Swallow the capsule whole with a full glass of water. Do not take it with milk or calcium-rich foods, as it may interfere with absorption. Follow the dosage schedule strictly for the best outcome.

Type of Dosage Available

• Capsules

Side Effects of Estramustine

• Nausea and vomiting
• Swelling in legs or ankles (fluid retention)
• Gynecomastia (breast enlargement in men)
• Headache
• High blood pressure
• Increased risk of blood clots
• Impotence and libido changes
• Liver dysfunction (in rare cases)

Safety Advice

• Not for use in women or children
• Avoid dairy products 2 hours before and after taking the dose
• Regularly monitor liver function and blood pressure
• Report signs of blood clot (pain, swelling, chest pain)
• Not to be used in patients with a history of clotting disorders or recent heart problems
• Inform your doctor about all other medications you're taking

Frequently Asked Questions (FAQs)

Q: What is Estramustine used for?

A: Estramustine is used to treat advanced or hormone-resistant prostate cancer in men.

Q: Can Estramustine cure prostate cancer?

A: It is not a cure but helps manage and slow the progression of prostate cancer.

Q: How long can I take Estramustine?

A: The duration depends on your condition and response to the treatment. Your doctor will determine how long you need to continue the medication.

Q: Can I take Estramustine with milk?

A: No, avoid taking Estramustine with milk or dairy products as they may affect absorption.

Q: Is Estramustine safe?

A: It is safe when used under medical supervision, but it may cause serious side effects like blood clots or liver problems in some patients.