Imipenem + Cilastatin

Introduction

Imipenem + Cilastatin is a combination antibiotic used to treat severe bacterial infections. Imipenem belongs to the carbapenem class of antibiotics that work against a wide range of bacteria, while Cilastatin prevents the breakdown of Imipenem in the kidneys, thereby increasing its effectiveness. This combination is generally prescribed in hospital settings for complicated infections such as those affecting the lungs, abdomen, urinary tract, skin, and joints. It is usually given by injection under medical supervision. Doctors recommend this medicine when other antibiotics are ineffective, making it a powerful option for serious bacterial infections.

Uses of Imipenem + Cilastatin

• Severe urinary tract infections
• Lung infections such as pneumonia
• Intra-abdominal infections
• Skin and soft tissue infections
• Bone and joint infections
• Septicemia (blood infections)
• Gynecological infections

How Imipenem + Cilastatin works

Imipenem kills bacteria by inhibiting the synthesis of their cell walls, while Cilastatin prevents its breakdown in the kidneys, ensuring higher levels of Imipenem remain active in the body to fight infections effectively.

Benefits of Imipenem + Cilastatin

• Broad-spectrum antibiotic effective against many bacteria
• Used in life-threatening infections
• Combination ensures stronger and longer activity
• Prevents resistance development in some cases
• Trusted treatment for hospital-acquired infections

How to take Imipenem + Cilastatin

This medicine is administered as an intravenous injection or infusion by a healthcare professional. The dosage depends on the severity of infection, age, kidney function, and response to treatment. Do not self-administer or skip doses, as it can reduce effectiveness. Always follow the doctor’s prescribed schedule.

Type of Dosage Available

• Injection (IV)
• Infusion (Hospital use)

Side effects of Imipenem + Cilastatin

• Nausea and vomiting
• Diarrhea
• Rash or itching
• Injection site pain
• Headache and dizziness
• Seizures (rare)
• Allergic reactions (severe cases)

Safety advice

• Not recommended for patients with allergy to beta-lactam antibiotics
• Use with caution in kidney disease
• Consult doctor if pregnant or breastfeeding
• Avoid driving if you feel dizzy or have seizures
• Take only under medical supervision

Frequently Asked Questions (FAQs)

Q. What is Imipenem + Cilastatin used for?
A It is used to treat severe bacterial infections such as pneumonia, urinary tract infections, abdominal and skin infections.

Q. How is Imipenem + Cilastatin given?
A It is given as an intravenous injection or infusion by a healthcare professional in hospital settings.

Q. Can I use Imipenem + Cilastatin at home?
A No, it should only be used under medical supervision due to its strength and potential side effects.

Q. What are the common side effects of Imipenem + Cilastatin?
A Common side effects include nausea, vomiting, diarrhea, rash, dizziness, and injection site pain.

Q. Is Imipenem + Cilastatin safe in pregnancy?
A It should only be used in pregnancy if prescribed by a doctor, after weighing risks and benefits.