Rifampicin + Isoniazid

Rifampicin + Isoniazid is a highly effective fixed-dose combination used in the treatment and prevention of tuberculosis (TB). Rifampicin is a powerful bactericidal antibiotic that kills bacteria, "Mycobacterium tuberculosis". Isoniazid, another first-line anti-TB drug, interferes with the formation of the bacterial cell wall. Together, these stop bacterial growth, prevent resistance, and support faster recovery. Consistent use as prescribed ensures successful treatment outcomes and prevents relapse or drug resistance.

Uses of Rifampicin + Isoniazid

• Treats Tuberculosis: Helps in inhibiting, eliminating, and killing the bacteria, preventing their growth. This dual action decreases bacterial load and alleviates symptoms such as cough, fever, and weight loss. It helps reduce the risk of spreading infection to others and treats Tuberculosis.
• Reduces Risk of Drug Resistance: Minimizes the risk of developing drug resistance by T.B. bacteria. This dual regimen provides a stronger attack on the bacteria, supports higher treatment success rates, helps in eliminating infection, and prevents relapse

How Rifampicin + Isoniazid Works

Rifampicin and Isoniazid work together to eliminate the tuberculosis bacteria. Rifampicin inhibits the bacteria` s ability to produce proteins, preventing their growth, while Isoniazid stops the bacteria from forming a protective cell wall. This combined action effectively kills the bacteria and prevents the infection from worsening.

Benefits of Rifampicin + Isoniazid

• Effectively treats tuberculosis
• Prevents the spread of TB bacteria
• Reduces the duration of TB treatment
• Minimizes the risk of drug-resistant TB
• Helps prevent TB in exposed individuals

How to Take Rifampicin + Isoniazid

• Take the medicine exactly as prescribed by your doctor.
• Consume it on an empty stomach, preferably 1 hour before or 2 hours after a meal.
• Swallow the tablet whole with a glass of water.
• Do not skip doses, as it may lead to drug resistance.
• Complete the full course of treatment even if you feel better.

Types of Dosage Available

• Rifampicin 150mg + Isoniazid 75mg Tablets
• Rifampicin 300mg + Isoniazid 150mg Tablets

Side Effects of Rifampicin + Isoniazid

• Common side effects: Nausea, vomiting, loss of appetite
• Less common: Dark urine, yellowing of skin or eyes (jaundice)
• Severe side effects: Liver damage, allergic reactions, numbness or tingling in hands and feet
• Contact a doctor if any side effects persist or worsen

Safety Advice

• Avoid alcohol consumption, as it may increase the risk of liver damage.
• Regular liver function tests are recommended during treatment.
• Not suitable for individuals with severe liver disease.
• Pregnant and breastfeeding women should consult a doctor before use.
• Inform your doctor about other medications to avoid drug interactions.

Frequently Asked Questions

Q: How long should I take Rifampicin + Isoniazid?
A: The duration of treatment varies but usually lasts 6 months or as directed by your doctor.

Q: Can I take Rifampicin + Isoniazid with food?
A: It is best taken on an empty stomach, but if you experience stomach upset, take it with a light meal.

Q: What should I do if I miss a dose?
A: Take the missed dose as soon as you remember. If it` s close to the next dose, skip it and continue your schedule.

Q: Can I stop taking the medicine if I feel better?
A: No, stopping early may cause TB to return and become drug-resistant. Complete the full course as prescribed.

Q: Is Rifampicin + Isoniazid safe for long-term use?
A: It is safe when taken as prescribed, but regular liver function monitoring is necessary during treatment.