Sacubitril + Valsartan

Sacubitril + Valsartan is a combination medication used primarily for managing heart failure with reduced ejection fraction (HFrEF), in which the left ventricle of the heart is not able to pump the blood properly. Sacubitril works by inhibiting the chemical action that causes constriction of blood vessels, thereby improving blood flow and heart function and reducing cardiac risk. On the other hand, valsartan works by blocking the chemical activity that causes an elevation in blood pressure and induces cardiac stress. This dual action improves heart function, reduces hospitalizations, and enhances overall quality of life for patients with chronic heart failure. By targeting multiple pathways in cardiovascular regulation, this combination therapy provides a more effective approach than single-agent treatment. It offers symptom relief, improved heart health, and long-term benefits in preventing disease progression.

Uses of Sacubitril + Valsartan

• Manages Heart Failure Symptoms: Helps reduce fluid buildup, shortness of breath, and tiredness. One medicine boosts natural body chemicals that remove salt and water, while the other eases heart strain. Together, they make the heart work better, improve energy, and help patients do daily activities more easily.
• Controls Blood Pressure: Lowers high blood pressure in heart failure patients. One drug relaxes blood vessels, while the other increases natural chemicals that widen vessels. This reduces heart workload, improves blood flow, and protects the heart, supporting better long-term heart health and function.
• Reduces Cardiac Stress: Protects the heart from damage caused by long-term pressure. It prevents heart enlargement and scarring, keeps the heart shape normal, slows disease progression, maintains heart function, and helps patients live more comfortably with chronic heart failure.
• Prevents Hospitalization Risk: Reduces the chance of needing hospital care from worsening heart failure. By controlling fluid buildup and blood pressure, it stabilizes heart function, reduces strain, improves heart output, and helps patients avoid sudden flare-ups, supporting safer long-term management.

How Sacubitril + Valsartan Works

Sacubitril inhibits neprilysin, increasing levels of substances that help relax blood vessels and reduce strain on the heart. Valsartan blocks angiotensin receptors, preventing blood vessel constriction and lowering blood pressure. Together, they enhance heart function and improve blood circulation.

Benefits of Sacubitril + Valsartan

• Improves heart efficiency
• Reduces blood pressure
• Prevents heart failure-related hospitalizations
• Enhances blood circulation
• Reduces strain on the heart

How to Take Sacubitril + Valsartan

Take Sacubitril + Valsartan exactly as prescribed by your doctor. Swallow the tablet with water, with or without food. Do not crush or chew the tablet. Follow the dosage instructions carefully to avoid complications.

Types of Dosage Available

• Tablet - 24 mg/26 mg
• Tablet - 49 mg/51 mg
• Tablet - 97 mg/103 mg

Side Effects of Sacubitril + Valsartan

• Dizziness
• Low blood pressure
• Increased potassium levels
• Kidney dysfunction
• Swelling in hands or feet
• Fatigue

Safety Advice

• Do not take if allergic to Sacubitril or Valsartan.
• Avoid if pregnant or breastfeeding.
• Monitor blood pressure regularly.
• Inform your doctor if you have kidney or liver disease.
• Avoid alcohol consumption while on this medication.
• Drink plenty of fluids to prevent dehydration.

Frequently Asked Questions (FAQs)

Q: What is Sacubitril + Valsartan used for?
A: It is used to treat heart failure and improve heart function.

Q: How long does Sacubitril + Valsartan take to show effects?
A: It may take a few weeks to show significant improvement in heart function.

Q: Can I stop taking Sacubitril + Valsartan suddenly?
A: No, stopping suddenly may worsen your condition. Consult your doctor before discontinuing.

Q: Does Sacubitril + Valsartan lower blood pressure?
A: Yes, it helps reduce high blood pressure by relaxing blood vessels.

Q: Can I take Sacubitril + Valsartan with other heart medications?
A: Consult your doctor before combining it with other heart medications.