Ado-trastuzumab Emtansine

Introduction

Ado-trastuzumab emtansine is a targeted cancer therapy used to treat HER2-positive breast cancer. It is a combination of trastuzumab (a monoclonal antibody) and emtansine (a chemotherapy drug). This advanced medication delivers chemotherapy directly to cancer cells by targeting the HER2 protein, minimizing damage to healthy cells. Ado-trastuzumab emtansine is typically used in patients who have previously received other HER2 therapies. It is given by intravenous infusion under medical supervision and plays a key role in improving outcomes in breast cancer patients.

Uses of Ado-trastuzumab emtansine

• Treatment of HER2-positive metastatic breast cancer
• Used in patients who have progressed on trastuzumab and taxane therapy
• Indicated for HER2-positive early breast cancer after surgery and prior treatment

How Ado-trastuzumab emtansine works

Ado-trastuzumab emtansine combines the HER2-targeting properties of trastuzumab with the cancer-killing power of emtansine. Trastuzumab binds to HER2 receptors on cancer cells, guiding the emtansine into the cell. Once inside, emtansine interferes with cancer cell division and causes cell death, offering a targeted and effective treatment.

Benefits of Ado-trastuzumab emtansine

• Specifically targets HER2-positive cancer cells
• Minimizes damage to healthy cells
• Improves survival in advanced breast cancer
• Reduces recurrence in early breast cancer patients

How to take Ado-trastuzumab emtansine

Ado-trastuzumab emtansine is administered as an intravenous (IV) infusion by a healthcare professional. It is usually given once every three weeks. The dose is based on the patient’s body weight and medical condition. Patients should follow the prescribed schedule and report any side effects to their doctor promptly.

Type of Dosage Available

• Intravenous injection (IV infusion)
• Available in vial form for hospital use

Side effects of Ado-trastuzumab emtansine

• Nausea and vomiting
• Fatigue
• Headache
• Low platelet count
• Liver enzyme abnormalities
• Heart problems in rare cases
• Shortness of breath
• Infusion-related reactions

Safety Advice

• Not recommended during pregnancy or breastfeeding
• Monitor liver function and platelet counts regularly
• Inform your doctor of any heart conditions
• Avoid live vaccines during treatment
• Use effective contraception during and after treatment

Frequently Asked Questions (FAQs)

Q1: What is Ado-trastuzumab emtansine used for?
Ado-trastuzumab emtansine is used to treat HER2-positive breast cancer, especially after failure of previous treatments.

Q2: How is Ado-trastuzumab emtansine administered?
It is given through intravenous infusion by a healthcare provider every three weeks.

Q3: Is Ado-trastuzumab emtansine chemotherapy?
Yes, it combines targeted therapy with chemotherapy for better cancer control.

Q4: Can Ado-trastuzumab emtansine cause hair loss?
Hair loss is not common, but some patients may experience it mildly.

Q5: Is it safe to use Ado-trastuzumab emtansine during pregnancy?
No, it is not safe during pregnancy. Women should use contraception while on treatment.