Antithymocyte Immunoglobulins
Uses of Antithymocyte Immunoglobulins
- Prevention of organ transplant rejection (kidney, heart, liver)
- Treatment of acute transplant rejection
- Treatment of aplastic anemia
- Immune suppression before bone marrow transplantation
How Antithymocyte Immunoglobulins Work
ATG works by binding to T-cells and marking them for destruction. This reduces immune activity, thereby lowering the chances of transplant rejection and controlling autoimmune reactions.
Benefits of Antithymocyte Immunoglobulins
- Prevents transplant rejection effectively
- Reduces the need for high-dose steroids
- Improves transplant success rates
- Helpful in severe aplastic anemia treatment
- Used in conditioning regimens before stem cell transplants
How to Take Antithymocyte Immunoglobulins
Antithymocyte Immunoglobulins are administered as an intravenous infusion in a hospital setting. The dosage and duration depend on the patient `s condition, weight, and response to therapy. Premedication with steroids, antihistamines, or antipyretics may be given to reduce infusion reactions.
Type of Dosage Available
- Intravenous injection (IV infusion only)
- Available in hospital or transplant centers
Side Effects of Antithymocyte Immunoglobulins
- Fever and chills
- Low white blood cell or platelet counts
- Rash and itching
- Breathing difficulties
- Serum sickness (fever, joint pain, rash)
- Increased risk of infections
Safety Advice
- Administer only under specialist supervision
- Monitor complete blood count and infection signs
- Avoid live vaccines during and after treatment
- Tell your doctor about any allergies to rabbits or horses
- Use with caution in pregnant or breastfeeding women
Frequently Asked Questions (FAQs)
Q: What are Antithymocyte Immunoglobulins used for?
A: They are used to prevent and treat rejection in organ transplants and to treat aplastic anemia.
Q: How are Antithymocyte Immunoglobulins given?
A: They are given as an intravenous infusion in a hospital under close medical supervision.
Q: Can Antithymocyte Immunoglobulins cause side effects?
A: Yes, common side effects include fever, rash, low blood cell counts, and infusion-related reactions.
Q: Are there any precautions before using ATG?
A: Yes, inform your doctor if you are allergic to rabbits or horses, or have a history of infections or immune conditions.
Q: Is it safe during pregnancy?
A: It should only be used during pregnancy if clearly needed and prescribed by a healthcare provider.
Medicine Not Available for Antithymocyte Immunoglobulins
Uses of Antithymocyte Immunoglobulins
- Prevention of organ transplant rejection (kidney, heart, liver)
- Treatment of acute transplant rejection
- Treatment of aplastic anemia
- Immune suppression before bone marrow transplantation
How Antithymocyte Immunoglobulins Work
ATG works by binding to T-cells and marking them for destruction. This reduces immune activity, thereby lowering the chances of transplant rejection and controlling autoimmune reactions.
Benefits of Antithymocyte Immunoglobulins
- Prevents transplant rejection effectively
- Reduces the need for high-dose steroids
- Improves transplant success rates
- Helpful in severe aplastic anemia treatment
- Used in conditioning regimens before stem cell transplants
How to Take Antithymocyte Immunoglobulins
Antithymocyte Immunoglobulins are administered as an intravenous infusion in a hospital setting. The dosage and duration depend on the patient `s condition, weight, and response to therapy. Premedication with steroids, antihistamines, or antipyretics may be given to reduce infusion reactions.
Type of Dosage Available
- Intravenous injection (IV infusion only)
- Available in hospital or transplant centers
Side Effects of Antithymocyte Immunoglobulins
- Fever and chills
- Low white blood cell or platelet counts
- Rash and itching
- Breathing difficulties
- Serum sickness (fever, joint pain, rash)
- Increased risk of infections
Safety Advice
- Administer only under specialist supervision
- Monitor complete blood count and infection signs
- Avoid live vaccines during and after treatment
- Tell your doctor about any allergies to rabbits or horses
- Use with caution in pregnant or breastfeeding women
Frequently Asked Questions (FAQs)
Q: What are Antithymocyte Immunoglobulins used for?
A: They are used to prevent and treat rejection in organ transplants and to treat aplastic anemia.
Q: How are Antithymocyte Immunoglobulins given?
A: They are given as an intravenous infusion in a hospital under close medical supervision.
Q: Can Antithymocyte Immunoglobulins cause side effects?
A: Yes, common side effects include fever, rash, low blood cell counts, and infusion-related reactions.
Q: Are there any precautions before using ATG?
A: Yes, inform your doctor if you are allergic to rabbits or horses, or have a history of infections or immune conditions.
Q: Is it safe during pregnancy?
A: It should only be used during pregnancy if clearly needed and prescribed by a healthcare provider.
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