Apalutamide

Introduction

Apalutamide is an anti-androgen medication primarily used to treat certain types of prostate cancer. It works by blocking the effect of androgens (male hormones) that fuel the growth of cancer cells in the prostate. Typically prescribed in combination with other treatments, Apalutamide helps slow down cancer progression and improve survival rates. This medicine is usually given to patients whose prostate cancer has not spread but is at high risk of doing so or is resistant to surgical or chemical castration.

Uses of Apalutamide

• Non-metastatic castration-resistant prostate cancer (nmCRPC)
• Metastatic castration-sensitive prostate cancer (mCSPC)
• Prostate cancer that no longer responds to hormonal or surgical treatment

How Apalutamide Works

Apalutamide is an androgen receptor inhibitor. It binds to androgen receptors and prevents male hormones like testosterone from activating these receptors. This action blocks the signals that prostate cancer cells need to grow and divide, slowing down or stopping cancer progression.

Benefits of Apalutamide

• Slows disease progression in prostate cancer
• Improves overall survival in patients with advanced prostate cancer
• Reduces the risk of metastasis (spread of cancer)
• Can be taken orally at home under medical supervision

How to Take Apalutamide

Apalutamide should be taken exactly as prescribed by your doctor. It is usually taken once daily with or without food. Swallow the tablets whole with water and do not crush or chew them. It is often prescribed alongside a gonadotropin-releasing hormone (GnRH) analog or after surgical castration.

Type of Dosage Available

• Apalutamide 60 mg Tablets

Side Effects of Apalutamide

• Fatigue
• Weight loss
• Joint pain
• Skin rash
• Increased risk of falls and fractures
• Hot flashes
• High blood pressure
• Seizures (rare)

Safety Advice

• Not recommended during pregnancy or breastfeeding
• Use effective contraception if your partner is of childbearing age
• Inform your doctor if you have a history of seizures or heart issues
• Regular blood pressure monitoring is advised
• Avoid activities requiring mental alertness until you know how the medicine affects you

Frequently Asked Questions (FAQs)

Q: What is Apalutamide used for?

A: Apalutamide is used to treat prostate cancer that is resistant to other hormone therapies or has a high risk of spreading.

Q: Can Apalutamide be taken with food?

A: Yes, Apalutamide can be taken with or without food.

Q: What should I do if I miss a dose?

A: If you miss a dose, take it as soon as you remember. If it’s close to your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

Q: Are there any serious side effects?

A: Serious side effects like seizures, high blood pressure, or severe rash can occur but are rare. Always consult your doctor if you notice any unusual symptoms.

Q: Can I stop taking Apalutamide on my own?

A: No, do not stop or change your dosage without consulting your doctor as it can affect the success of your treatment.