Avelumab

Introduction

Avelumab is a monoclonal antibody used as an immunotherapy treatment for certain types of cancers. It works by helping the body’s immune system detect and destroy cancer cells more effectively. Avelumab is prescribed for advanced cancers like Merkel cell carcinoma, urothelial carcinoma, and non-small cell lung cancer. This medication is administered intravenously in a clinical setting and is part of a newer class of drugs known as immune checkpoint inhibitors. It is considered a promising therapy due to its ability to improve survival rates in specific cancer types.

Uses of Avelumab

• Merkel cell carcinoma (MCC)
• Urothelial carcinoma (bladder cancer)
• Non-small cell lung cancer (NSCLC)
• Renal cell carcinoma (kidney cancer), in combination with axitinib

How Avelumab Works

Avelumab is an anti-PD-L1 monoclonal antibody. It works by blocking the PD-L1 protein on cancer cells, which normally helps them evade immune detection. By inhibiting PD-L1, Avelumab reactivates T-cells to recognize and attack the cancer cells, boosting the body’s immune response against tumors.

Benefits of Avelumab

• Enhances immune response against cancer
• Improves survival rates in advanced cancers
• Reduces tumor progression
• Non-chemotherapy option for certain cancers

How to Take Avelumab

Avelumab is given by intravenous (IV) infusion under the supervision of a healthcare provider. It is usually administered every 2 weeks. The dosage depends on the patient’s weight, medical condition, and response to treatment. Always follow the doctor’s instructions precisely.

Type of Dosage Available

• Injection (intravenous infusion)
• 200 mg/10 mL single-dose vial

Side Effects of Avelumab

• Fatigue
• Nausea
• Fever
• Diarrhea
• Rash
• Loss of appetite
• Infusion-related reactions
• Severe immune-related conditions (e.g., pneumonitis, hepatitis)

Safety Advice

• Not recommended during pregnancy or breastfeeding
• Regular liver, kidney, and thyroid tests may be required
• Inform your doctor about any autoimmune conditions
• Monitor for signs of infusion-related reactions
• Use contraception during treatment and for some time after

Frequently Asked Questions (FAQs)

Q: What is Avelumab used for?

Avelumab is used to treat certain types of advanced cancers, including Merkel cell carcinoma, bladder cancer, and lung cancer.

Q: How is Avelumab administered?

Avelumab is given through an intravenous (IV) infusion, usually every 2 weeks under medical supervision.

Q: Can Avelumab be taken during pregnancy?

No, Avelumab is not recommended during pregnancy as it may harm the unborn baby.

Q: What should I do if I miss a dose?

Inform your doctor immediately. They will reschedule your infusion as necessary.

Q: Is Avelumab a chemotherapy drug?

No, Avelumab is an immunotherapy drug that works by enhancing the immune system’s ability to fight cancer.