Bosentan

Bosentan is a prescription medicine used to treat pulmonary arterial hypertension (PAH), a condition characterized by high blood pressure in the arteries of the lungs. It helps improve the ability to exercise, slows the worsening of symptoms, and enhances quality of life. Bosentan works by blocking endothelin, a natural substance in the body that causes blood vessels to narrow. By relaxing and widening these blood vessels, Bosentan improves blood flow and reduces blood pressure in the lungs.

Uses of Bosentan

• Treatment of pulmonary arterial hypertension (PAH)
• Improves exercise capacity in PAH patients
• Slows progression of PAH-related symptoms

How Bosentan Works

Bosentan is an endothelin receptor antagonist. It blocks the action of endothelin-1, a chemical that causes blood vessels to constrict. This leads to the widening of blood vessels, especially in the lungs, reducing blood pressure and improving oxygen delivery.

Benefits of Bosentan

• Reduces pulmonary blood pressure
• Improves breathing and stamina
• Slows the worsening of PAH
• Delays the need for other advanced PAH therapies

How to Take Bosentan

Bosentan is taken orally with or without food, usually twice daily. Follow your doctor’s instructions carefully. Do not stop or change the dose without consulting your physician. Regular blood tests may be required to monitor liver function and hemoglobin levels.

Type of Dosage Available

• Tablets – 62.5 mg
• Tablets – 125 mg

Side Effects of Bosentan

• Headache
• Flushing
• Low blood pressure
• Liver function abnormalities
• Swelling of the legs and ankles (edema)
• Decreased red blood cell count (anemia)

Safety Advice

• Regular liver function tests are mandatory
• Not recommended during pregnancy – may harm the unborn baby
• Use effective birth control during treatment
• Avoid alcohol to protect liver health
• Inform your doctor of all current medications

Frequently Asked Questions (FAQs)

Q: What is Bosentan used for?
A: Bosentan is used to treat pulmonary arterial hypertension and improve exercise capacity.

Q: Is Bosentan safe during pregnancy?
A: No. Bosentan is harmful during pregnancy and should not be used unless advised by a doctor with proper precautions.

Q: How long does Bosentan take to work?
A: Improvements in symptoms may be seen within weeks, but full effects can take several months.

Q: Can Bosentan be taken with food?
A: Yes, Bosentan can be taken with or without food.

Q: Is Bosentan a cure for PAH?
A: No. It helps manage symptoms and slows disease progression, but it is not a cure.