Busulfan

Busulfan is a chemotherapy medication primarily used to treat chronic myeloid leukemia (CML) and as part of the conditioning regimen before a bone marrow or stem cell transplant. It belongs to the class of drugs known as alkylating agents. Busulfan works by slowing or stopping the growth of cancer cells in the body. It is usually administered under strict medical supervision due to its powerful effects and potential side effects.

Uses of Busulfan

• Treatment of chronic myeloid leukemia (CML)
• Pre-conditioning before bone marrow or stem cell transplantation
• Reduction of white blood cell count in blood disorders

How Busulfan works

Busulfan works by binding to DNA in cancer cells, causing damage that prevents them from multiplying. This helps slow or stop the growth of abnormal cells in leukemia and prepares the bone marrow for transplantation.

Benefits of Busulfan

• Effective in treating chronic myeloid leukemia
• Prepares the body for successful bone marrow transplant
• Reduces high white blood cell counts

How to take Busulfan

Busulfan is usually administered as an oral tablet or intravenous infusion in a hospital setting. Dosage and frequency are determined by your doctor based on your weight, condition, and treatment plan. Follow all instructions carefully and do not adjust the dose on your own.

Type of Dosage Available

• Oral tablets
• Intravenous injection

Side effects of Busulfan

• Nausea and vomiting
• Loss of appetite
• Hair loss
• Low blood cell counts (anemia, infection risk)
• Liver toxicity or pulmonary fibrosis (rare but serious)

Safety advice

• Use only under medical supervision
• Regular blood tests are needed to monitor side effects
• Inform your doctor if you are pregnant or planning pregnancy
• May increase risk of infection—avoid contact with sick individuals
• Report any unusual bruising, bleeding, or fatigue to your doctor

Frequently Asked Questions (FAQs)

Q. What is Busulfan used for?
A. It is used to treat chronic myeloid leukemia and prepare patients for bone marrow transplantation.


Q. How is Busulfan administered?
A. It can be given orally in tablet form or as an intravenous infusion in a clinical setting.


Q. Are there any serious side effects of Busulfan?
A. Yes, serious side effects include low blood counts, liver damage, and lung issues. Monitoring is essential.


Q. Can Busulfan be used during pregnancy?
A. No, it can harm the unborn baby. Use effective contraception and consult your doctor.


Q. Is Busulfan safe for long-term use?
A. It is usually used short-term under medical supervision due to its strong effects and side effects.