Ceftazidime + Avibactam

Ceftazidime + Avibactam is a combination antibiotic medication used to treat serious bacterial infections. Ceftazidime, a third-generation cephalosporin, works by inhibiting the growth of bacteria, while Avibactam is a beta-lactamase inhibitor that enhances the effectiveness of Ceftazidime by preventing bacteria from breaking it down. This combination is primarily used for complicated urinary tract infections, pneumonia, and intra-abdominal infections caused by susceptible bacteria.

Uses of Ceftazidime + Avibactam

• Treatment of complicated urinary tract infections (cUTI)
• Management of complicated intra-abdominal infections (cIAI)
• Treatment of hospital-acquired pneumonia (HAP)
• Effective against multi-drug-resistant bacteria

How Ceftazidime + Avibactam works

Ceftazidime inhibits the bacterial cell wall synthesis, leading to bacterial cell death. Avibactam, on the other hand, blocks beta-lactamase enzymes produced by bacteria, which would otherwise degrade Ceftazidime. The combination enhances the overall antibacterial activity and combats resistant bacterial strains.

Benefits of Ceftazidime + Avibactam

• Highly effective against multidrug-resistant (MDR) bacteria
• Works against a wide range of gram-negative and gram-positive bacteria
• Reduces the risk of treatment failure in severe bacterial infections
• Can be used in the treatment of infections that are resistant to other antibiotics

How to take Ceftazidime + Avibactam

Ceftazidime + Avibactam is administered by intravenous (IV) infusion. The exact dosage and duration of treatment depend on the type and severity of the infection, as well as the patient's overall health condition. It is important to follow the prescribed regimen and consult a healthcare provider if you experience any side effects or have concerns about the treatment.

Type of Dosage Available

• Intravenous infusion (IV)

Side effects of Ceftazidime + Avibactam

• Common side effects may include nausea, diarrhea, or rash
• Possible liver enzyme changes
• Headache and dizziness
• Allergic reactions (rare but severe), including anaphylaxis
• Blood cell count abnormalities, such as low white blood cell count (neutropenia)

Safety advice

• Inform your healthcare provider about any allergies, especially to penicillin or cephalosporins
• Use with caution in patients with kidney disease, as dosage adjustments may be required
• Monitor for signs of an allergic reaction, especially if you have a history of allergies to antibiotics
• Pregnant or breastfeeding women should consult a doctor before using this medication
• Follow the prescribed dosage and administration schedule carefully

Frequently Asked Questions (FAQs)

Q: What is Ceftazidime + Avibactam used for?
A: Ceftazidime + Avibactam is used to treat serious bacterial infections, including complicated urinary tract infections, pneumonia, and intra-abdominal infections caused by multi-drug-resistant bacteria.

Q: How is Ceftazidime + Avibactam administered?
A: Ceftazidime + Avibactam is given through an intravenous (IV) infusion, usually under the supervision of a healthcare professional.

Q: Are there any common side effects?
A: Common side effects may include nausea, diarrhea, rash, or changes in liver enzymes. It is important to report any unusual symptoms to your healthcare provider.

Q: Is Ceftazidime + Avibactam safe for people with kidney disease?
A: Ceftazidime + Avibactam should be used with caution in patients with kidney disease. Dosage adjustments may be necessary, and your healthcare provider will monitor kidney function during treatment.

Q: Can Ceftazidime + Avibactam be used during pregnancy?
A: Ceftazidime + Avibactam should only be used during pregnancy if deemed necessary by a doctor. Always consult with a healthcare provider before using any medication during pregnancy or while breastfeeding.