Dabrafenib

Introduction

Dabrafenib is a targeted cancer therapy used to treat specific types of cancer caused by abnormal BRAF genes. It is commonly prescribed for patients with advanced or metastatic melanoma, non-small cell lung cancer, or thyroid cancer that test positive for the BRAF V600 mutation. Dabrafenib belongs to a class of medications known as BRAF inhibitors and is often used alone or in combination with other drugs. It works by slowing or stopping the growth of cancer cells, offering improved outcomes for patients with certain genetic profiles.

Uses of Dabrafenib

• Treatment of unresectable or metastatic melanoma with BRAF V600E mutation
• Used in combination therapy for BRAF V600E-mutant non-small cell lung cancer (NSCLC)
• Effective against BRAF V600E-positive anaplastic thyroid cancer

How Dabrafenib Works

Dabrafenib blocks the activity of the BRAF protein, which is involved in cell growth and division. In cancers with the BRAF V600 mutation, this protein is overactive, leading to uncontrolled tumor growth. By inhibiting BRAF, Dabrafenib disrupts the cancer cell signaling pathway, slowing or stopping cancer progression.

Benefits of Dabrafenib

• Targets cancer cells with specific genetic mutations
• Delays progression of metastatic melanoma
• Improves survival rates when used in combination therapy
• Can be taken orally, allowing for at-home treatment

How to Take Dabrafenib

Dabrafenib is usually taken orally twice a day, at least one hour before or two hours after a meal. Follow your doctor’s prescription strictly and do not adjust the dose without medical advice. Swallow the capsules whole with water. Regular monitoring through blood tests or scans may be required during treatment.

Type of Dosage Available

• Capsules: 50 mg
• Capsules: 75 mg

Side Effects of Dabrafenib

• Common: Fever, fatigue, headache, joint pain, nausea
• Severe: Skin reactions, eye problems, bleeding, high blood sugar, liver dysfunction
• May increase risk of other cancers (e.g., squamous cell carcinoma)

Safety Advice

• Not recommended during pregnancy or breastfeeding
• Monitor blood sugar if diabetic
• Avoid sun exposure; use sunscreen regularly
• Inform doctor of any history of heart, liver, or eye conditions
• Report symptoms like vision changes or unusual bleeding immediately

Frequently Asked Questions (FAQs)

Q: What is Dabrafenib used for?

A: Dabrafenib is used to treat cancers with a BRAF V600 mutation, including melanoma, NSCLC, and thyroid cancer.

Q: How should I take Dabrafenib?

A: Take Dabrafenib twice daily on an empty stomach, exactly as prescribed by your doctor.

Q: Can Dabrafenib be taken with food?

A: No, it should be taken at least 1 hour before or 2 hours after a meal.

Q: What are the common side effects?

A: Fever, fatigue, headache, and nausea are common side effects. Serious side effects should be reported to a doctor.

Q: Is Dabrafenib safe during pregnancy?

A: No, Dabrafenib should not be used during pregnancy due to risk of harm to the unborn baby.