Deferasirox

Deferasirox is an iron chelator medication used to treat chronic iron overload in patients who have received frequent blood transfusions, such as those with thalassemia, sickle cell disease, or other anemias. It works by binding to excess iron in the body and removing it through urine. Excess iron can accumulate in organs like the heart and liver, causing damage, so Deferasirox helps prevent complications related to iron overload.

Uses of Deferasirox

• Treatment of chronic iron overload due to blood transfusions (e.g., thalassemia, sickle cell disease)
• Prevention of organ damage caused by iron overload
• Used in certain cases of non-transfusion-dependent thalassemia to manage iron buildup

How Deferasirox works

Deferasirox works by binding to excess iron in the body and forming a complex that is excreted in the urine. This helps prevent the harmful accumulation of iron in vital organs, such as the heart and liver, thus reducing the risk of organ damage.

Benefits of Deferasirox

• Helps reduce iron levels in patients with chronic iron overload
• Prevents iron buildup-related damage to organs like the liver and heart
• Improves quality of life by reducing the complications of iron overload
• Oral administration provides a convenient alternative to other iron chelation treatments

How to take Deferasirox

Deferasirox is typically taken as a daily oral tablet. It is best taken on an empty stomach, at least 30 minutes before food, with a full glass of water. The dosage will vary based on the individual’s weight and iron levels, and should be adjusted by your healthcare provider. Swallow the tablet whole, and do not crush or chew it. Regular blood tests will be required to monitor iron levels and organ function during treatment.

Type of Dosage Available

• Oral tablets
• Oral dispersible tablets (for easier swallowing)

Side effects of Deferasirox

• Gastrointestinal issues, such as nausea, vomiting, or diarrhea
• Skin rashes or itching
• Elevated liver enzymes
• Kidney problems, including changes in kidney function tests
• Headaches
• Increased risk of infections due to lowered white blood cell count
• Hearing loss (rare)

Safety advice

• Regular blood tests are required to monitor liver, kidney, and heart function
• Drink plenty of fluids to help prevent kidney issues
• Inform your doctor if you have a history of kidney or liver disease
• Notify your healthcare provider about any other medications you are taking
• Take precautions to avoid infections while using this medication
• Do not take Deferasirox if you are pregnant or breastfeeding unless advised by your doctor

Frequently Asked Questions (FAQs)

Q: What is Deferasirox used for?
A: Deferasirox is used to treat chronic iron overload caused by blood transfusions, preventing damage to vital organs like the heart and liver.

Q: How does Deferasirox work?
A: Deferasirox binds to excess iron in the body, allowing it to be removed via urine and preventing iron buildup in organs.

Q: Can Deferasirox cause kidney problems?
A: Yes, Deferasirox can affect kidney function, so regular monitoring of kidney health is necessary during treatment.

Q: How long does it take for Deferasirox to lower iron levels?
A: It may take several weeks to months to notice a reduction in iron levels. Regular blood tests will help track progress.

Q: Are there any foods to avoid while taking Deferasirox?
A: There are no specific food restrictions, but it’s important to take Deferasirox on an empty stomach for optimal absorption.