Fingolimod

Fingolimod is an immunomodulatory medicine primarily used to treat relapsing forms of multiple sclerosis (MS). It belongs to a class of drugs called sphingosine 1-phosphate receptor modulators. Fingolimod works by reducing the movement of white blood cells into the central nervous system, thereby helping prevent the immune system from attacking the nerves. It helps reduce the frequency of MS flare-ups and slows the progression of physical disability.

Uses of Fingolimod

• Treatment of relapsing-remitting multiple sclerosis (RRMS)
• Reduction in frequency of MS exacerbations
• Delays progression of disability associated with MS

How Fingolimod works

Fingolimod acts on sphingosine-1-phosphate (S1P) receptors, causing certain white blood cells (lymphocytes) to be retained in lymph nodes. This limits their ability to enter the central nervous system and damage nerve cells, which helps reduce inflammation and nerve damage in multiple sclerosis.

Benefits of Fingolimod

• Reduces relapse rate in MS patients
• Slows the worsening of physical disability
• Oral administration, offering convenience over injectables
• Improves quality of life in MS patients

How to take Fingolimod

Fingolimod is taken orally once a day with or without food. The first dose is usually given under medical supervision due to potential heart effects. Follow the dosage instructions strictly as prescribed by your neurologist.

Type of Dosage Available

• Capsules

Side effects of Fingolimod

• Headache
• Fatigue
• Back pain
• Increased liver enzymes
• Diarrhea
• Bradycardia (slow heart rate)
• Macular edema (vision changes)
• Increased risk of infections

Safety advice

• Do not use if you have a history of heart problems without doctor clearance
• Eye exams are recommended before and during treatment
• Avoid live vaccines during treatment
• Not recommended during pregnancy and breastfeeding
• Regular liver function and blood count monitoring is necessary

Frequently Asked Questions (FAQs)

Q. What condition is Fingolimod used to treat?
A. Fingolimod is used to treat relapsing forms of multiple sclerosis (MS).

Q. Can Fingolimod cure multiple sclerosis?
A. No, it does not cure MS but helps manage symptoms and reduce flare-ups.

Q. Why is the first dose of Fingolimod monitored?
A. The first dose can slow the heart rate, so monitoring ensures safety.

Q. Can I take vaccines while on Fingolimod?
A. Live vaccines should be avoided; consult your doctor before taking any vaccine.

Q. Is Fingolimod safe during pregnancy?
A. No, Fingolimod is not recommended during pregnancy and should be discontinued under medical guidance.