Infliximab

Infliximab is a monoclonal antibody used in the treatment of several autoimmune diseases, including rheumatoid arthritis, Crohn’s disease, ulcerative colitis, and ankylosing spondylitis. It works by targeting and inhibiting tumor necrosis factor-alpha (TNF-α), a substance in the body that causes inflammation. By blocking TNF-α, Infliximab helps to reduce inflammation, pain, and damage associated with autoimmune conditions. It is usually administered through an intravenous (IV) infusion under medical supervision.

Uses of Infliximab

• Treatment of moderate to severe rheumatoid arthritis
• Management of Crohn’s disease and ulcerative colitis
• Used in treating ankylosing spondylitis and psoriatic arthritis
• Helps to reduce inflammation and slow disease progression in autoimmune diseases

How Infliximab Works

Infliximab works by targeting and blocking the action of TNF-α, a pro-inflammatory cytokine involved in the immune response. By inhibiting TNF-α, Infliximab reduces inflammation in the body, which is the underlying cause of pain and damage in many autoimmune diseases. It helps to control the immune system’s overactive response, reducing symptoms and preventing further damage to affected tissues.

Benefits of Infliximab

• Reduces inflammation and pain in autoimmune diseases
• Helps improve joint function in rheumatoid arthritis
• Can significantly reduce symptoms and flare-ups in Crohn’s disease and ulcerative colitis
• Slows the progression of autoimmune conditions and prevents further tissue damage
• Improves the quality of life for individuals with chronic autoimmune diseases

How to Take Infliximab

Infliximab is administered through an intravenous (IV) infusion in a healthcare setting. The infusion is typically given over a period of 2 hours. The frequency of infusions may vary depending on the condition being treated. For example, patients with rheumatoid arthritis may receive infusions every 6-8 weeks after the initial loading doses. Your healthcare provider will determine the appropriate dosage and schedule for your specific condition.

Type of Dosage Available

• Intravenous Infusion

Side Effects of Infliximab

• Headache, nausea, or dizziness
• Injection site reactions such as pain, swelling, or redness
• Increased risk of infections, including upper respiratory infections
• Possible allergic reactions, such as rash or difficulty breathing
• Rarely, serious side effects such as liver problems or heart failure may occur

Safety Advice

• Inform your doctor of any infections, heart conditions, or liver problems before starting Infliximab
• Monitor for signs of infection during treatment, as Infliximab can increase the risk of infections
• Use caution if you are pregnant or breastfeeding, as Infliximab should be used only when the benefits outweigh the risks
• Regular monitoring of liver function and blood cell counts is recommended during treatment
• Do not receive live vaccines while using Infliximab

Frequently Asked Questions (FAQs)

Q. What is Infliximab used for?
A. Infliximab is used to treat autoimmune diseases, including rheumatoid arthritis, Crohn’s disease, ulcerative colitis, and ankylosing spondylitis. It helps to reduce inflammation and manage symptoms.

Q. How is Infliximab administered?
A. Infliximab is administered through an intravenous (IV) infusion in a healthcare setting. The infusion is given over a period of 2 hours, and the frequency of infusions depends on the condition being treated.

Q. Can Infliximab cause side effects?
A. Yes, common side effects include headache, nausea, and injection site reactions. Serious side effects such as infections, allergic reactions, or liver problems may also occur, though they are rare.

Q. Is Infliximab safe during pregnancy?
A. Infliximab should be used during pregnancy only if the potential benefits outweigh the risks. Consult your doctor if you are pregnant or breastfeeding before starting treatment with Infliximab.

Q. How long does it take for Infliximab to start working?
A. Infliximab may take several weeks to show noticeable improvements in symptoms, especially in conditions like rheumatoid arthritis and Crohn’s disease. The effects may vary based on the condition being treated.