Isoflurane

Isoflurane is a volatile, inhalational general anesthetic commonly used during surgeries to induce and maintain anesthesia. It causes a reversible loss of consciousness and sensation, allowing pain-free surgical procedures. Isoflurane is known for its rapid onset and recovery characteristics, making it a preferred choice in many clinical settings.

Uses of Isoflurane

• Induction of general anesthesia
• Maintenance of anesthesia during surgery
• Used in both minor and major surgical procedures

How it works

Isoflurane works by depressing the central nervous system. It enhances the activity of inhibitory neurotransmitters like GABA, leading to a decrease in brain activity and loss of consciousness. It also affects pain pathways, thereby providing analgesic effects.

Benefits

• Rapid onset and recovery from anesthesia
• Effective muscle relaxation
• Provides a controlled depth of anesthesia
• Stable cardiovascular profile during anesthesia

How to take

Isoflurane is administered only by trained healthcare professionals in a hospital or clinical setting. It is delivered via an inhalational route using an anesthesia machine and vaporizer. The dose and duration depend on the type and length of surgery.

Type of Dosage Available

• Inhalation liquid for vaporization

Side effects

• Nausea and vomiting (post-operative)
• Hypotension (low blood pressure)
• Respiratory depression
• Shivering
• Increased salivation
• Rarely, malignant hyperthermia

Safety advice

• To be used only under medical supervision
• Not recommended for use in patients with a history of malignant hyperthermia
• Monitor vital signs continuously during use
• May interact with other anesthetics and neuromuscular blockers
• Use caution in patients with liver or cardiovascular conditions

Frequently Asked Questions (FAQs)

Q. Is Isoflurane safe for children?
A. Yes, Isoflurane can be used in children but only under the supervision of an experienced anesthesiologist.

Q. How long does it take for Isoflurane to wear off?
A. Recovery from Isoflurane is generally quick, usually within minutes after discontinuation, depending on the duration of use.

Q. Can Isoflurane cause any long-term effects?
A. Long-term effects are rare, but prolonged use or repeated exposure may affect liver or kidney function in sensitive individuals.

Q. Does Isoflurane cause sleep or sedation?
A. Yes, it induces unconsciousness and deep sedation suitable for surgical procedures.

Q. Is Isoflurane better than other anesthetics?
A. It offers good control over anesthesia depth and quick recovery, but the choice of anesthetic depends on the patient and surgical needs.