Mercaptopurine

Mercaptopurine is an antimetabolite medicine primarily used to treat certain types of cancer, such as acute lymphoblastic leukemia (ALL). It may also be prescribed for some autoimmune conditions like inflammatory bowel disease. Mercaptopurine works by interfering with the growth of cancer cells and suppressing the immune system.

Uses of Mercaptopurine

• Treatment of acute lymphoblastic leukemia (ALL)
• Management of inflammatory bowel diseases (off-label)
• As part of chemotherapy regimens

How Mercaptopurine works

Mercaptopurine is a purine antagonist that interferes with the synthesis of DNA and RNA. This inhibits the growth and multiplication of cancer cells and immune cells, which is useful in cancer and autoimmune disorders.

Benefits of Mercaptopurine

• Helps in remission of certain cancers like ALL
• Suppresses abnormal immune responses
• Can be used in combination with other cancer medications

How to take Mercaptopurine

Take Mercaptopurine exactly as prescribed by your doctor, usually once daily. It can be taken with or without food, but it should be taken at the same time each day. Do not take it with milk or dairy products, as they may reduce its effectiveness.

Type of Dosage Available

• Tablet

Side effects of Mercaptopurine

• Nausea and vomiting
• Loss of appetite
• Low blood cell counts
• Liver enzyme elevation
• Increased risk of infections

Safety advice

• Regularly monitor blood counts and liver function during use
• Avoid alcohol to prevent liver damage
• Inform your doctor if you develop fever or signs of infection
• Not recommended during pregnancy or breastfeeding unless clearly needed
• Use effective contraception during treatment

Frequently Asked Questions (FAQs)

Q. What is Mercaptopurine used for?
A. Mercaptopurine is mainly used to treat acute lymphoblastic leukemia and may also be prescribed for autoimmune conditions like Crohn’s disease.

Q. How long does Mercaptopurine take to work?
A. It may take several weeks to months to see the full benefits, depending on the condition being treated.

Q. Can I take Mercaptopurine with food?
A. Yes, but it should not be taken with milk or dairy products. It’s best taken at the same time each day.

Q. What precautions should I take while on Mercaptopurine?
A. Regular blood tests are necessary to monitor your blood counts and liver function. Avoid people with infections and practice good hygiene.

Q. Is Mercaptopurine safe during pregnancy?
A. It is not recommended during pregnancy unless the benefits outweigh the risks. Use contraception while taking this medicine.