Moclobemide

Moclobemide is an antidepressant medication that belongs to a class known as reversible inhibitors of monoamine oxidase A (RIMA). It is primarily used for the treatment of major depressive disorder and social anxiety. Unlike traditional MAO inhibitors, moclobemide has fewer dietary restrictions and a better safety profile.

Uses

• Treatment of depression
• Management of social anxiety disorder

How it works

Moclobemide works by inhibiting the enzyme monoamine oxidase A, which is responsible for breaking down neurotransmitters such as serotonin, norepinephrine, and dopamine in the brain. By increasing the levels of these mood-regulating chemicals, moclobemide helps relieve symptoms of depression and anxiety.

Benefits

• Improves mood in depressive disorders
• Reduces symptoms of social anxiety
• Fewer food interactions compared to older MAO inhibitors
• Generally well-tolerated with a favorable safety profile

How to take

Moclobemide is taken orally, usually after meals to reduce stomach upset. The dose and frequency depend on the condition being treated and individual response. It should be taken consistently and not discontinued abruptly without medical advice.

Type of Dosage Available

• Tablets

Side effects

• Insomnia
• Dizziness
• Headache
• Dry mouth
• Nausea
• Agitation or restlessness

Safety advice

• Do not take with other antidepressants, especially SSRIs or MAOIs
• Avoid consuming large amounts of tyramine-rich foods
• Inform your doctor if you have liver problems or bipolar disorder
• Not recommended during pregnancy or breastfeeding unless prescribed
• Avoid alcohol and operating machinery until you know how the medicine affects you

Frequently Asked Questions (FAQs)

Q. What is moclobemide used for?
A. Moclobemide is used to treat major depression and social anxiety disorder by increasing levels of mood-regulating neurotransmitters in the brain.

Q. How long does moclobemide take to work?
A. It may take 1 to 3 weeks to notice significant improvement in symptoms, though some patients feel better sooner.

Q. Can moclobemide be taken with food?
A. Yes, it is usually taken after meals to minimize stomach upset.

Q. Is moclobemide addictive?
A. Moclobemide is not considered addictive, but it should not be stopped suddenly without medical advice.

Q. Are there food restrictions with moclobemide?
A. Unlike older MAOIs, moclobemide has fewer dietary restrictions, but it is still advisable to limit high-tyramine foods like aged cheese and red wine.