Natalizumab

Introduction

Natalizumab is a prescription medicine that belongs to the class of monoclonal antibodies. It is primarily used in the treatment of autoimmune conditions such as multiple sclerosis (MS) and Crohn’s disease. Natalizumab works by preventing immune cells from attacking healthy tissue, thereby reducing inflammation and disease progression. It is usually prescribed when other treatments have not been effective. This composition is given under the guidance of a healthcare professional through intravenous (IV) infusion.

Uses of Natalizumab

• Treatment of relapsing forms of multiple sclerosis (MS)
• Management of moderate to severe Crohn’s disease in adults unresponsive to conventional therapies

How Natalizumab works

Natalizumab works by blocking the movement of immune cells (lymphocytes) into the brain and spinal cord. It targets and binds to the α4-integrin protein on the surface of white blood cells, preventing them from entering areas of inflammation. This reduces nerve damage and inflammation in MS and gut inflammation in Crohn’s disease.

Benefits of Natalizumab

• Slows down the progression of multiple sclerosis
• Reduces the number of MS relapses
• Improves mobility and reduces neurological disability
• Alleviates symptoms of Crohn’s disease
• Effective when other therapies fail

How to take Natalizumab

Natalizumab is administered through an intravenous (IV) infusion, usually once every 4 weeks in a clinical setting. The dosage and frequency are determined by your doctor based on your medical condition and response to treatment. It is important not to miss scheduled infusions for the medicine to be effective.

Type of Dosage Available

• Intravenous infusion (IV injection)
• Usually supplied in single-use vials for hospital use

Side effects of Natalizumab

• Headache
• Fatigue
• Nausea
• Joint pain
• Increased risk of infections
• Progressive multifocal leukoencephalopathy (PML – a rare but serious brain infection)
• Allergic reactions during infusion (fever, chills, rash)

Safety Advice

• Not recommended during pregnancy unless prescribed by your doctor
• Breastfeeding mothers should consult their doctor before use
• Regular monitoring for signs of infection or brain conditions is necessary
• Inform your doctor about any history of liver disease, cancer, or infections
• Should be used with caution in elderly patients

Frequently Asked Questions (FAQs)

Q: What is Natalizumab used for?
A: Natalizumab is used to treat relapsing multiple sclerosis and moderate to severe Crohn’s disease when other treatments are not effective.

Q: How is Natalizumab administered?
A: It is given as an intravenous (IV) infusion once every four weeks in a hospital or clinic.

Q: Are there any serious side effects?
A: Yes, rare but serious side effects include brain infection (PML), severe allergic reactions, and infections. Regular checkups are essential.

Q: Can I take Natalizumab during pregnancy?
A: Use during pregnancy should only be under medical supervision. Always consult your doctor before use.

Q: Can I stop Natalizumab suddenly?
A: No, do not stop or miss doses without consulting your healthcare provider, as it may lead to a relapse or worsening of symptoms.