Palbociclib

Palbociclib is an anti-cancer medication used for the treatment of hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) breast cancer. It belongs to a class of drugs known as CDK4/6 inhibitors, which help slow down the growth and spread of cancer cells. Palbociclib is often used in combination with hormone therapy, such as letrozole or fulvestrant, to enhance its effectiveness in treating advanced or metastatic breast cancer.

Uses of Palbociclib

• Treatment of HR+/HER2- advanced breast cancer
• Used in combination with hormone therapy (aromatase inhibitors or fulvestrant)
• Helps in slowing cancer progression and improving survival rates

How Palbociclib Works

Palbociclib works by inhibiting cyclin-dependent kinases 4 and 6 (CDK4/6), which are proteins responsible for cell division. By blocking these proteins, the drug prevents cancer cells from multiplying uncontrollably, thereby slowing the growth and spread of the tumor.

Benefits of Palbociclib

• Slows down the progression of advanced breast cancer
• Enhances the effectiveness of hormonal therapies
• Improves overall survival in patients with HR+/HER2- breast cancer
• Offers an oral treatment option, reducing hospital visits

How to Take Palbociclib

Palbociclib is taken orally in the form of capsules or tablets. It is usually taken once daily for 21 consecutive days, followed by a 7-day break before starting the next cycle. It should be taken with food and at the same time every day for the best results. Always follow your doctor’s dosage instructions.

Types of Dosage Available

• Palbociclib 75 mg Capsules
• Palbociclib 100 mg Capsules
• Palbociclib 125 mg Capsules

Side Effects of Palbociclib

• Fatigue
• Nausea and vomiting
• Loss of appetite
• Diarrhea or constipation
• Low white blood cell count (increased risk of infections)
• Hair thinning or hair loss
• Skin rash
• Increased risk of bleeding

Safety Advice

• Monitor blood counts regularly as the drug can lower white blood cells
• Avoid grapefruit or grapefruit juice as it may interfere with the drug’s absorption
• Inform your doctor if you experience signs of infection (fever, chills, sore throat)
• Use effective contraception during treatment, as the drug may harm an unborn baby
• Avoid alcohol consumption to reduce the risk of liver toxicity
• Do not stop the medication without consulting your doctor

Frequently Asked Questions (FAQs)

Q. What is Palbociclib used for?
A. Palbociclib is used for the treatment of hormone receptor-positive, HER2-negative advanced breast cancer, usually in combination with hormonal therapy.

Q. How long should I take Palbociclib?
A. The duration of treatment depends on your condition and response to the medication. Your doctor will determine the appropriate treatment plan.

Q. Can Palbociclib cause hair loss?
A. Yes, hair thinning or mild hair loss may occur in some patients, but it is usually not severe.

Q. Is Palbociclib a chemotherapy drug?
A. No, Palbociclib is a targeted therapy that works by blocking specific proteins involved in cancer cell growth. It is not a traditional chemotherapy drug.

Q. Can I take Palbociclib on an empty stomach?
A. No, Palbociclib should be taken with food to ensure proper absorption and effectiveness.