Plecanatide

Plecanatide is a guanylate cyclase-C (GC-C) agonist used in the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C) in adults. It helps promote regular bowel movements by increasing fluid secretion in the intestines and accelerating transit.

Uses

• Chronic idiopathic constipation (CIC)
• Irritable bowel syndrome with constipation (IBS-C)

How it works

Plecanatide is a structural analog of human uroguanylin. It activates guanylate cyclase-C receptors in the intestinal lining, which increases levels of cyclic GMP. This stimulates secretion of chloride and bicarbonate into the intestinal lumen via CFTR channels, resulting in increased fluid secretion and motility, thereby easing bowel movements.

Benefits

• Improves bowel regularity
• Relieves abdominal bloating and discomfort
• Reduces straining during defecation
• Improves quality of life in IBS-C patients

How to take

Take Plecanatide exactly as prescribed by your doctor. It is usually taken once daily on an empty stomach, preferably at the same time each day. The tablet should be swallowed whole with water and should not be crushed or chewed.

Type of Dosage Available

• Tablets

Side effects

• Diarrhea
• Abdominal distension
• Flatulence
• Dizziness
• Dehydration (in severe diarrhea cases)

Safety advice

• Not recommended for children under 6 years of age due to risk of dehydration
• Use with caution in patients with severe diarrhea or gastrointestinal obstruction
• Inform your doctor if you are pregnant or breastfeeding
• Maintain hydration, especially if experiencing loose stools

Frequently Asked Questions (FAQs)

Q. What is Plecanatide used for?
A. Plecanatide is used to treat chronic idiopathic constipation and irritable bowel syndrome with constipation in adults.

Q. How long does Plecanatide take to work?
A. Some people may experience relief within the first week, but it can take a few weeks for full benefit. Regular use is important.

Q. Can Plecanatide cause diarrhea?
A. Yes, diarrhea is a common side effect. If it becomes severe, consult your doctor immediately.

Q. Is it safe to take Plecanatide daily?
A. Yes, it is typically prescribed for once-daily use. Do not exceed the prescribed dose.

Q. Can Plecanatide be taken with food?
A. It is recommended to take it on an empty stomach, preferably before the first meal of the day.