Plerixafor

Introduction

Plerixafor is a prescription medication used in combination with a granulocyte-colony stimulating factor (G-CSF) to help collect stem cells from the blood for transplantation. It is mainly prescribed for patients with certain types of blood cancers such as multiple myeloma and non-Hodgkin's lymphoma. By increasing the number of stem cells released from the bone marrow into the bloodstream, Plerixafor helps doctors harvest these cells for later use in stem cell transplantation, offering a vital treatment option in cancer therapy.

Uses of Plerixafor

• Mobilization of hematopoietic stem cells
• Preparation for autologous stem cell transplantation
• Used in patients with multiple myeloma
• Used in non-Hodgkin’s lymphoma patients

How Plerixafor works

Plerixafor works by blocking the CXCR4 receptor on bone marrow cells, disrupting their bond with the stromal cell-derived factor (SDF-1). This action causes stem cells to move from the bone marrow into the bloodstream, making them easier to collect for transplantation.

Benefits of Plerixafor

• Effective stem cell mobilization when G-CSF alone is insufficient
• Reduces need for multiple apheresis sessions
• Increases success rate of stem cell transplantation
• Improves overall treatment outcomes in blood cancer patients

How to take Plerixafor

Plerixafor is administered via a subcutaneous injection, usually in a hospital or clinical setting. It is given approximately 11 hours before stem cell collection. Your doctor will decide the correct dose based on your body weight and other medical conditions. Follow your healthcare provider’s instructions carefully and do not self-administer unless trained to do so.

Type of Dosage Available

• Injection (Subcutaneous)
• Prefilled syringes or vials

Side effects of Plerixafor

• Common: Diarrhea, nausea, headache, injection site redness
• Less common: Dizziness, joint pain, flatulence
• Severe (rare): Low white blood cell count, allergic reactions

Safety Advice

• Not recommended during pregnancy unless necessary
• Breastfeeding should be avoided
• Inform your doctor about kidney issues before use
• Should be used under medical supervision only
• Monitor blood counts regularly during treatment

Frequently Asked Questions (FAQs)

Q: What is Plerixafor used for?

A: Plerixafor is used to mobilize stem cells from the bone marrow into the bloodstream for collection before stem cell transplantation in cancer patients.

Q: Is Plerixafor safe?

A: Yes, when used under medical supervision. However, it may cause side effects like nausea, diarrhea, and injection site reactions.

Q: How is Plerixafor given?

A: It is given as a subcutaneous injection, usually 11 hours before the collection of stem cells.

Q: Can Plerixafor be taken at home?

A: It should be administered in a clinical setting by a healthcare professional unless advised otherwise by your doctor.

Q: Can pregnant women take Plerixafor?

A: Plerixafor should be avoided during pregnancy unless absolutely necessary and prescribed by a doctor.