Polymyxin B

Polymyxin B is an antibiotic used to treat serious bacterial infections, especially those caused by Gram-negative bacteria. It works by disrupting the bacterial cell membrane, effectively killing the bacteria. Polymyxin B is typically administered through injection or applied topically in combination with other antibiotics or corticosteroids for treating eye, ear, and skin infections. Due to its potency, it is often reserved for infections that do not respond to other antibiotics.

Uses of Polymyxin B

• Treatment of serious Gram-negative bacterial infections
• Used in urinary tract infections (UTIs)
• Treatment of meningitis caused by susceptible bacteria
• Part of topical ointments for skin and eye infections
• Used in combination therapy for multidrug-resistant bacteria

How Polymyxin B Works

Polymyxin B works by binding to the outer membrane of Gram-negative bacteria, disrupting membrane integrity and leading to leakage of cellular contents, ultimately killing the bacteria.

Benefits of Polymyxin B

• Highly effective against resistant Gram-negative bacteria
• Can be used when other antibiotics fail
• Available in both injectable and topical forms
• Often included in combination antibiotic therapies
• Helps manage hospital-acquired infections

How to Take Polymyxin B

Polymyxin B is administered via injection by a healthcare professional in a hospital setting. For minor infections, it may be used as a topical ointment or eye/ear drops. Follow your doctor's directions precisely. Do not self-medicate or adjust the dosage on your own.

Types of Dosage Available

• Injection
• Topical ointment
• Eye drops
• Ear drops

Side Effects of Polymyxin B

Common side effects:

• Pain or redness at injection site
• Rash or skin irritation (topical use)
• Eye irritation (in eye drops)

Severe side effects:

• Kidney toxicity
• Nerve damage (neurotoxicity)
• Dizziness or numbness
• Breathing difficulties (rare but serious)

Safety Advice

• Use only under medical supervision
• Monitor kidney function during treatment
• Inform doctor of existing kidney or nerve issues
• Avoid use in pregnancy unless prescribed
• Do not mix with other injectable drugs without advice

Frequently Asked Questions (FAQs)

Q: What is Polymyxin B used for?
A: It is used to treat severe bacterial infections, especially those resistant to other antibiotics.

Q: Is Polymyxin B safe?
A: It is effective but must be used with caution due to possible kidney and nerve toxicity.

Q: Can I use Polymyxin B ointment on cuts?
A: Yes, if it's prescribed for bacterial skin infections, but avoid using it on large wounds or for long durations.

Q: How is Polymyxin B administered?
A: It can be given by injection in hospitals or applied topically in creams, eye drops, or ear drops.

Q: Is Polymyxin B available over the counter?
A: No, it should be used under medical supervision due to its potential side effects.