Poractant Alfa

Introduction

Poractant Alfa is a lung surfactant medication used primarily in neonatal intensive care. It contains surfactant extracted from porcine lungs, designed to help premature infants breathe more easily. This compound reduces surface tension in the lungs, preventing alveolar collapse, and supporting better oxygen exchange. It is a life-saving treatment in cases of Respiratory Distress Syndrome (RDS), commonly seen in preterm babies whose lungs have not yet fully developed. Poractant Alfa plays a vital role in stabilizing newborns and improving their chances of survival during critical stages of development.

Uses of Poractant Alfa

• Treatment of Respiratory Distress Syndrome (RDS) in premature infants
• Prevention of RDS in neonates at risk
• Enhances lung function in neonates with surfactant deficiency

How Poractant Alfa works

Poractant Alfa mimics the natural surfactant found in human lungs. It reduces the surface tension within the alveoli (air sacs), allowing them to remain open during breathing. This facilitates easier gas exchange and improves lung function, especially in premature infants who cannot produce enough surfactant naturally.

Benefits of Poractant Alfa

• Rapid improvement in lung compliance and oxygenation
• Reduces mortality rates in premature infants
• Minimizes need for mechanical ventilation
• Clinically proven and widely used in neonatal care

How to take Poractant Alfa

Poractant Alfa is administered intratracheally by a healthcare professional, typically in a neonatal intensive care unit. The dosage depends on the weight of the newborn and the severity of the condition. It is not taken orally or by injection into the bloodstream. A second or third dose may be given if the infant continues to show signs of RDS.

Type of Dosage Available

• Intratracheal suspension (240 mg/3 mL and 120 mg/1.5 mL vials)

Side effects of Poractant Alfa

• Bradycardia (slow heart rate)
• Hypoxia (low oxygen levels)
• Apnea (temporary cessation of breathing)
• Pulmonary hemorrhage (rare but serious)
• Airway obstruction during administration

Safety Advice

• Should only be administered by trained professionals in a clinical setting
• Continuous monitoring of oxygen and heart rate is essential
• Not suitable for use in adults or older children
• Check for potential allergic reactions to porcine proteins
• Use with caution in infants with bleeding disorders

Frequently Asked Questions (FAQs)

Q: What is Poractant Alfa used for?

A: Poractant Alfa is used to treat or prevent Respiratory Distress Syndrome (RDS) in premature infants by helping their lungs function properly.

Q: How is Poractant Alfa given?

A: It is given directly into the baby’s windpipe (trachea) by a trained healthcare provider in a neonatal intensive care unit.

Q: Is Poractant Alfa safe for all newborns?

A: It is generally safe when used under medical supervision but should not be used in full-term infants without RDS or those with other contraindications.

Q: Can Poractant Alfa cause any serious side effects?

A: While rare, serious side effects like pulmonary hemorrhage and bradycardia can occur and require immediate medical attention.

Q: How soon does Poractant Alfa start working?

A: Improvement in breathing and oxygen levels can often be seen within minutes after administration.