Recombinant Human Parathyroid Hormone

Introduction

Recombinant Human Parathyroid Hormone (rhPTH) is a synthetic form of the naturally occurring parathyroid hormone, primarily used to manage conditions like osteoporosis and hypoparathyroidism. It helps regulate calcium and phosphate levels in the body, promoting bone formation and reducing fracture risk in individuals with weak or brittle bones. rhPTH mimics the effects of the natural hormone, thereby enhancing calcium absorption and bone density. This medicine is typically prescribed when other forms of treatment, such as calcium and vitamin D supplements, are not sufficient. It is administered under the supervision of a healthcare professional.

Uses of Recombinant Human Parathyroid Hormone

• Treatment of osteoporosis in postmenopausal women
• Management of osteoporosis in men at high risk of fracture
• Treatment of glucocorticoid-induced osteoporosis
• Long-term management of chronic hypoparathyroidism
• Improves calcium regulation in patients with parathyroid hormone deficiency

How Recombinant Human Parathyroid Hormone works

Recombinant Human Parathyroid Hormone works by mimicking the body’s natural parathyroid hormone. It stimulates bone-forming cells (osteoblasts), enhances calcium absorption in the intestines, and reduces calcium loss through urine. This helps to strengthen bones and regulate calcium and phosphate balance.

Benefits of Recombinant Human Parathyroid Hormone

• Improves bone density and strength
• Reduces risk of spinal and other fractures
• Helps regulate calcium and phosphate in the body
• Effective for patients who do not respond to other therapies
• Supports bone regeneration in osteoporosis patients

How to take Recombinant Human Parathyroid Hormone

This medicine is administered via a subcutaneous injection (under the skin), typically in the thigh or abdomen. It is usually taken once daily, and patients may be trained to self-administer it at home. Always follow the dosage and administration instructions given by your doctor. Do not exceed the recommended dose.

Type of Dosage Available

• Subcutaneous Injection (Prefilled Pen)

Side effects of Recombinant Human Parathyroid Hormone

• Nausea
• Leg cramps
• Joint pain
• Dizziness or light-headedness
• Headache
• Increased blood calcium levels (hypercalcemia)

Safety advice

• Do not use longer than prescribed (usually not beyond 2 years)
• Monitor calcium levels regularly
• Avoid in patients with bone cancer or a history of radiation therapy
• Not recommended during pregnancy or breastfeeding unless advised
• Store injection in the refrigerator as per label instructions

Frequently Asked Questions (FAQs)

Q: What is Recombinant Human Parathyroid Hormone used for?
A: It is used for treating osteoporosis and chronic hypoparathyroidism by helping regulate calcium and improve bone health.

Q: How is Recombinant Human Parathyroid Hormone administered?
A: It is given as a subcutaneous injection once a day, usually in the thigh or abdomen.

Q: Can I take this medicine with calcium supplements?
A: Yes, but your doctor will guide you on the right dose of calcium and vitamin D to take alongside it.

Q: Are there any serious side effects?
A: Some patients may experience high calcium levels, which can lead to nausea, muscle weakness, or confusion. Regular monitoring is necessary.

Q: How long can I use Recombinant Human Parathyroid Hormone?
A: It is usually prescribed for a maximum of 2 years due to potential risk of bone-related tumors with long-term use.