Rifabutin

Rifabutin is an antibiotic primarily used to treat and prevent infections caused by Mycobacterium tuberculosis and Mycobacterium avium complex (MAC). It belongs to the rifamycin group of drugs and works by inhibiting bacterial RNA synthesis, which helps stop the growth of bacteria. Rifabutin is often prescribed to patients with HIV/AIDS to prevent MAC infections and is also used in tuberculosis treatment regimens when resistance or intolerance to other rifamycins exists.

Uses of Rifabutin

• Treatment of tuberculosis (TB)
• Prevention and treatment of Mycobacterium avium complex (MAC) infections
• Used in HIV-infected patients to prevent opportunistic infections

How Rifabutin works

Rifabutin inhibits bacterial RNA polymerase, which blocks RNA synthesis and stops bacterial growth, effectively controlling bacterial infections.

Benefits of Rifabutin

• Effective against tuberculosis bacteria
• Helps prevent MAC infections in immunocompromised patients
• Can be used in cases resistant to other rifamycins
• Supports combination therapy for better infection control

How to take Rifabutin

Take Rifabutin orally with or without food as prescribed by your doctor. Do not skip doses and complete the full course even if you feel better. Follow dosing instructions carefully to avoid resistance.

Type of Dosage Available

• Oral capsules

Side effects of Rifabutin

• Orange-red discoloration of body fluids
• Gastrointestinal upset (nausea, diarrhea)
• Rash or skin reactions
• Fatigue
• Fever
• Elevated liver enzymes

Safety advice

• Inform your doctor about any liver problems
• Avoid missing doses to prevent resistance
• Use caution if you are pregnant or breastfeeding
• Do not stop medication without consulting your doctor
• Avoid alcohol during treatment

Frequently Asked Questions (FAQs)

Q. What is Rifabutin used for?
A. It is used to treat tuberculosis and prevent Mycobacterium avium complex infections.

Q. How should I take Rifabutin?
A. Take it orally as prescribed, completing the full course even if you feel better.

Q. Can Rifabutin change the color of my urine?
A. Yes, it may cause orange-red discoloration of urine and other body fluids, which is harmless.

Q. Are there any serious side effects?
A. Serious side effects are rare but include liver problems and allergic reactions. Consult your doctor if you notice unusual symptoms.

Q. Can I drink alcohol while taking Rifabutin?
A. It is recommended to avoid alcohol as it can increase the risk of liver damage.