Rifampicin + Isoniazid + Ethambutol + Pyrazinamide + Vitamin B6 (Pyridoxine)

This fixed-dose combination is primarily used in the treatment of tuberculosis (TB). It contains four anti-tuberculosis drugs—Rifampicin, Isoniazid, Ethambutol, and Pyrazinamide—along with Vitamin B6 (Pyridoxine) to prevent nerve damage caused by Isoniazid. Together, these medicines work synergistically to kill the bacteria causing TB, reduce symptoms, and prevent relapse. This combination ensures patient compliance and is especially effective in the intensive phase of TB treatment.

Uses of Rifampicin + Isoniazid + Ethambutol + Pyrazinamide + Vitamin B6 (Pyridoxine)

Treatment of pulmonary and extrapulmonary tuberculosis
Initial intensive phase of TB therapy
Prevention of nerve damage due to Isoniazid

How Rifampicin + Isoniazid + Ethambutol + Pyrazinamide + Vitamin B6 works

Each component targets the tuberculosis bacteria differently—killing the bacteria, inhibiting their growth, or preventing resistance. Vitamin B6 prevents peripheral neuropathy caused by Isoniazid.

Benefits of Rifampicin + Isoniazid + Ethambutol + Pyrazinamide + Vitamin B6

Effective against active tuberculosis infections
Reduces bacterial resistance
Improves patient compliance with single-dose therapy
Prevents nerve damage from Isoniazid

How to take Rifampicin + Isoniazid + Ethambutol + Pyrazinamide + Vitamin B6

Take the medicine on an empty stomach, preferably in the morning, or as prescribed by your doctor. Follow the full course without missing doses, even if symptoms improve.

Type of Dosage Available

Tablet

Side effects of Rifampicin + Isoniazid + Ethambutol + Pyrazinamide + Vitamin B6

Nausea and vomiting
Loss of appetite
Skin rash or itching
Liver dysfunction
Vision disturbances
Peripheral neuropathy

Safety advice

Avoid alcohol during treatment
Inform your doctor of liver or kidney conditions
Monitor liver function regularly
Use with caution in elderly patients
Not recommended during pregnancy unless prescribed

Frequently Asked Questions (FAQs)

Q. What is this combination medicine used for?
A. It is used to treat active tuberculosis and prevent nerve damage from Isoniazid.

Q. Can this medicine be taken with food?
A. It is best taken on an empty stomach, but your doctor may advise otherwise based on tolerance.

Q. Why is Vitamin B6 included in this combination?
A. Vitamin B6 helps prevent nerve damage (peripheral neuropathy) caused by Isoniazid.

Q. What should I avoid while taking this medicine?
A. Avoid alcohol and hepatotoxic drugs, and inform your doctor about other ongoing treatments.

Q. Is it safe for long-term use?
A. It is safe for the prescribed duration, usually during the intensive phase of TB treatment.