Rucaparib

Introduction

Rucaparib is an oral anticancer medication that belongs to a class of drugs known as PARP inhibitors. It is primarily used for the treatment of certain types of cancer, especially ovarian and prostate cancers associated with BRCA gene mutations. Rucaparib works by interfering with cancer cell DNA repair mechanisms, leading to cell death. This targeted action makes it an effective option for patients with advanced or relapsed cancers. It is generally prescribed after other treatments have failed or in specific genetic profiles. Rucaparib is available in tablet form and should be taken under strict medical supervision.

Uses of Rucaparib

• Treatment of advanced ovarian cancer
• Maintenance therapy for relapsed ovarian cancer
• Treatment of metastatic castration-resistant prostate cancer with BRCA mutations

How Rucaparib works

Rucaparib inhibits the enzyme poly (ADP-ribose) polymerase (PARP), which helps repair damaged DNA in cells. Cancer cells with BRCA mutations heavily rely on PARP for survival. By blocking PARP activity, Rucaparib causes DNA damage to accumulate, leading to cancer cell death while sparing normal cells.

Benefits of Rucaparib

• Effective in targeting BRCA-mutated cancer cells
• Delays cancer progression in relapsed ovarian cancer
• Convenient oral tablet form
• Improves progression-free survival rates

How to take Rucaparib

Rucaparib should be taken exactly as prescribed by a doctor. The usual dose is taken twice daily with or without food. Swallow the tablets whole with water. Do not crush, chew, or break the tablets. Treatment duration depends on the individual response and tolerance. Regular blood tests may be required to monitor progress and side effects.

Type of Dosage Available

• Rucaparib 200 mg Tablet
• Rucaparib 250 mg Tablet
• Rucaparib 300 mg Tablet

Side effects of Rucaparib

• Nausea and vomiting
• Fatigue
• Loss of appetite
• Low red or white blood cell counts
• Abdominal pain
• Elevated liver enzymes
• Shortness of breath (in severe cases)

Safety Advice

• Inform your doctor about any liver or kidney issues
• Avoid alcohol and grapefruit juice during treatment
• Not recommended during pregnancy or breastfeeding
• Use effective contraception during and after treatment
• Monitor blood counts and liver function regularly

Frequently Asked Questions (FAQs)

Q: What is Rucaparib used for?

A: Rucaparib is used for treating ovarian and prostate cancers with BRCA gene mutations, especially after other treatments have not worked.

Q: Can I take Rucaparib on an empty stomach?

A: Yes, Rucaparib can be taken with or without food. Follow your doctor’s advice for the best results.

Q: Are there any food restrictions while using Rucaparib?

A: Avoid grapefruit and its juice as it may increase the side effects of the medicine.

Q: How long should I take Rucaparib?

A: The duration varies depending on the patient’s condition and response to treatment. Your doctor will decide the length of therapy.

Q: Can pregnant women take Rucaparib?

A: No, Rucaparib is not safe during pregnancy as it may harm the fetus. Effective contraception is necessary during treatment.