Selegiline

Selegiline is a medication primarily used in the treatment of Parkinson’s disease and depression. It belongs to a class of drugs called monoamine oxidase inhibitors (MAOIs), specifically MAO-B inhibitors. Selegiline works by increasing the levels of certain chemicals in the brain that help improve motor function and mood. In Parkinson’s disease, it is often used in combination with other drugs like levodopa to enhance its effectiveness. In lower doses, it helps control symptoms of Parkinsonism, while higher doses may be prescribed for managing major depressive disorder.

Uses of Selegiline

• Treatment of Parkinson’s disease
• Used as an adjunct to levodopa therapy
• Management of major depressive disorder (in higher doses)
• Improvement of motor symptoms in neurodegenerative diseases

How Selegiline works

Selegiline selectively inhibits the enzyme monoamine oxidase-B (MAO-B), which breaks down dopamine in the brain. This leads to increased dopamine levels, improving mood and motor control.

Benefits of Selegiline

• Improves motor symptoms in Parkinson’s disease
• Reduces the "wearing-off" effect of levodopa
• May delay the progression of Parkinson’s symptoms
• Helpful in treating symptoms of depression
• Neuroprotective effects in long-term use

How to take Selegiline

Selegiline should be taken exactly as prescribed by your doctor. It is usually taken orally, with or without food. The dose varies depending on the condition being treated. Do not exceed the recommended dose. Avoid consuming foods high in tyramine when taking higher doses, especially for depression, due to risk of severe hypertension.

Type of Dosage Available

• Oral tablets
• Oral disintegrating tablets
• Transdermal patch (for depression)

Side effects of Selegiline

• Insomnia
• Dizziness
• Headache
• Nausea
• Mouth ulcers (with oral disintegrating form)
• Increased blood pressure (at high doses)
• Hallucinations (rare)
• Serotonin syndrome (when combined with certain medications)

Safety advice

• Avoid foods rich in tyramine at high doses
• Inform doctor about all medications and supplements
• Use cautiously in patients with cardiovascular disease
• Not recommended in children
• May cause drowsiness or dizziness—avoid driving if affected
• Consult doctor before using during pregnancy or breastfeeding

Frequently Asked Questions (FAQs)

Q. What is Selegiline used for?
A. Selegiline is used to treat Parkinson’s disease and, in higher doses, major depressive disorder.

Q. How does Selegiline help in Parkinson’s disease?
A. It increases dopamine levels in the brain, improving movement and reducing symptoms.

Q. Can Selegiline be taken with food?
A. Yes, it can be taken with or without food. Follow your doctor’s instructions.

Q. What should I avoid while taking Selegiline?
A. Avoid high-tyramine foods like aged cheese and alcohol, especially at higher doses.

Q. Is Selegiline safe for long-term use?
A. Yes, when used under medical supervision, it is generally safe for long-term treatment.