Teplizumab

Introduction

Teplizumab is a monoclonal antibody medication developed to help delay the onset of Type 1 diabetes in individuals at high risk. It works by modulating the immune system to prevent it from attacking insulin-producing beta cells in the pancreas. Teplizumab is a groundbreaking therapy for delaying the progression of autoimmune diabetes, giving patients more time before requiring insulin therapy. It is administered under medical supervision through intravenous infusion and is approved for use in individuals showing early signs of Type 1 diabetes.

Uses of Teplizumab

• Delays the onset of Stage 3 Type 1 diabetes
• Used in patients with Stage 2 Type 1 diabetes (at-risk individuals)
• Slows autoimmune destruction of beta cells

How Teplizumab Works

Teplizumab is an anti-CD3 monoclonal antibody that binds to CD3 receptors on T-cells, modulating their activity. By doing so, it reduces the autoimmune attack on pancreatic beta cells, preserving insulin production and delaying the clinical onset of Type 1 diabetes in at-risk patients.

Benefits of Teplizumab

• Delays the need for insulin therapy
• Preserves natural insulin production for a longer period
• Improves long-term outcomes in early-stage diabetes
• Reduces the burden of daily diabetes management

How to Take Teplizumab

Teplizumab is given as a once-daily intravenous infusion over a 14-day course. The infusion must be administered in a clinical setting by a healthcare professional. Patients are monitored during and after infusion for any side effects or allergic reactions. The dosage schedule is based on body weight and is adjusted accordingly.

Type of Dosage Available

• Intravenous infusion (Injection)

Side Effects of Teplizumab

• Rash
• Headache
• Low white blood cell count
• Nausea
• Fever
• Fatigue
• Hypersensitivity reactions (rare)

Safety Advice

• Not recommended during pregnancy or breastfeeding without medical advice
• Inform your doctor of any active infections before starting treatment
• Regular monitoring of white blood cell count is required
• Administered only under clinical supervision
• Report any allergic or severe side effects immediately

Frequently Asked Questions (FAQs)

Q: What is Teplizumab used for?

A: Teplizumab is used to delay the onset of Type 1 diabetes in at-risk individuals, particularly those diagnosed with Stage 2 Type 1 diabetes.

Q: How is Teplizumab given?

A: It is administered as an intravenous infusion once daily over 14 consecutive days in a healthcare setting.

Q: Can Teplizumab cure diabetes?

A: No, it does not cure diabetes. It delays the progression and need for insulin therapy in patients who are at high risk.

Q: Are there any serious side effects?

A: Serious side effects are rare but can include allergic reactions and low white blood cell counts. Patients are closely monitored during treatment.

Q: Is Teplizumab approved for children?

A: Yes, it is approved for individuals aged 8 years and older who are at risk of developing Type 1 diabetes. Consult your doctor for eligibility.