Ustekinumab

Introduction

Ustekinumab is a biologic medication used to treat chronic inflammatory conditions such as plaque psoriasis, psoriatic arthritis, Crohn’s disease, and ulcerative colitis. It belongs to a class of drugs called monoclonal antibodies and works by targeting specific proteins in the immune system that cause inflammation. Ustekinumab is typically prescribed when conventional therapies fail or are not well tolerated. This medication helps in reducing symptoms, improving skin condition, and achieving long-term remission in autoimmune diseases.

Uses of Ustekinumab

• Treatment of moderate to severe plaque psoriasis
• Management of psoriatic arthritis
• Treatment of Crohn’s disease (moderate to severe)
• Treatment of ulcerative colitis
• Used in cases unresponsive to other treatments

How Ustekinumab works

Ustekinumab works by targeting and inhibiting two specific proteins in the body—interleukin-12 (IL-12) and interleukin-23 (IL-23)—which play a key role in causing inflammation. By blocking these proteins, Ustekinumab reduces inflammation and helps manage symptoms in autoimmune conditions like psoriasis and inflammatory bowel diseases.

Benefits of Ustekinumab

• Reduces inflammation and flare-ups
• Improves skin condition in psoriasis
• Promotes remission in Crohn’s disease and colitis
• Improves joint pain and mobility in psoriatic arthritis
• Fewer doses needed compared to other biologics

How to take Ustekinumab

Ustekinumab is administered by subcutaneous injection or intravenous infusion. The first dose is often given under medical supervision, followed by maintenance doses every 8 to 12 weeks. Your doctor will determine the exact schedule and dosage based on your condition and response to treatment.

Type of Dosage Available

• Pre-filled injection syringe
• Intravenous infusion (IV)
• Single-use vial

Side effects of Ustekinumab

• Upper respiratory infections
• Headache
• Fatigue or weakness
• Redness or pain at the injection site
• Joint pain
• Serious infections (rare)
• Allergic reactions (rare)

Safety advice

• Do not take if allergic to Ustekinumab
• Consult your doctor if pregnant or breastfeeding
• Avoid live vaccines during treatment
• Inform your doctor about ongoing infections or TB
• Regular monitoring is advised during long-term use

Frequently Asked Questions (FAQs)

Q. What conditions does Ustekinumab treat?
A. Ustekinumab is used to treat plaque psoriasis, psoriatic arthritis, Crohn’s disease, and ulcerative colitis.

Q. How is Ustekinumab administered?
A. It is given either as a subcutaneous injection or as an intravenous infusion by a healthcare provider.

Q. How often do I need to take Ustekinumab?
A. After the initial dose, maintenance doses are usually given every 8 to 12 weeks.

Q. Are there any serious side effects?
A. Serious side effects are rare but may include infections and allergic reactions. Inform your doctor immediately if symptoms appear.

Q. Can I take Ustekinumab during pregnancy?
A. Consult your doctor before taking Ustekinumab during pregnancy or breastfeeding.