Verteporfin

Introduction

Verteporfin is a medication primarily used in photodynamic therapy to treat abnormal blood vessel growth in the eye, especially in conditions like age-related macular degeneration (AMD). It is a light-activated drug that targets and helps destroy unwanted blood vessels in the retina, which can cause vision loss if left untreated. Administered intravenously, Verteporfin works when exposed to a special laser, offering a targeted treatment with minimal effect on surrounding tissues.

Uses of Verteporfin

• Wet age-related macular degeneration (Wet AMD)
• Pathologic myopia-related choroidal neovascularization
• Ocular histoplasmosis syndrome
• Central serous chorioretinopathy (off-label use)

How Verteporfin Works

Verteporfin is activated by a specific wavelength of laser light after it is injected into the bloodstream. Once activated in the presence of oxygen, it produces a form of reactive oxygen that selectively damages and closes abnormal blood vessels in the retina without affecting healthy ones, thereby preventing further vision damage.

Benefits of Verteporfin

• Helps preserve central vision in patients with wet AMD
• Minimally invasive and targeted therapy
• Reduces risk of further vision loss
• Effective in combination with laser treatment

How to Take Verteporfin

Verteporfin is administered intravenously by a healthcare professional. After infusion, a special non-thermal laser is applied to the eye to activate the drug. The entire procedure usually takes less than an hour and is performed in an outpatient setting. Follow your doctor’s instructions and avoid sunlight exposure for 48 hours post-treatment.

Type of Dosage Available

• Intravenous injection (IV infusion)

Side Effects of Verteporfin

• Visual disturbances (blurred vision, decreased sharpness)
• Injection site pain or redness
• Photosensitivity reactions (rash, swelling)
• Back pain during infusion
• Temporary vision darkening
• Headache or dizziness
• Rare allergic reactions

Safety Advice

• Avoid direct sunlight and bright indoor light for at least 48 hours
• Inform your doctor about any liver conditions
• Not recommended for patients with porphyria
• Use only under professional supervision
• Tell your doctor if you are pregnant or breastfeeding

Frequently Asked Questions (FAQs)

Q: What is Verteporfin used for?

A: Verteporfin is used to treat wet age-related macular degeneration and other conditions involving abnormal blood vessels in the retina.

Q: How is Verteporfin administered?

A: It is given through an intravenous infusion followed by laser treatment to activate the drug in the eye.

Q: Can I go outdoors after Verteporfin treatment?

A: No, you should avoid sunlight and bright light for at least 48 hours after the treatment to prevent skin reactions.

Q: Is Verteporfin safe for pregnant women?

A: It should only be used during pregnancy if clearly needed. Always consult your doctor before use.

Q: What are common side effects of Verteporfin?

A: Side effects may include temporary vision changes, injection site reactions, and photosensitivity.