Alprostadil

Alprostadil is a medication primarily used to treat erectile dysfunction (ED) in men and to improve blood circulation in certain medical conditions. It is a synthetic version of prostaglandin E1 (PGE1), a substance naturally found in the body that helps widen blood vessels and improve blood flow. Alprostadil may be administered as an injection directly into the penis or as a urethral suppository. It is also used in newborns with congenital heart defects to maintain the patency of the ductus arteriosus before surgery.

Uses of Alprostadil

• Treatment of erectile dysfunction (ED)
• Improves blood circulation in peripheral vascular disease
• Keeps ductus arteriosus open in newborns with congenital heart defects
• Used in diagnostic testing for ED

How Alprostadil Works

Alprostadil works by relaxing the blood vessels and smooth muscles, allowing increased blood flow to specific areas. In erectile dysfunction, it helps increase blood flow to the penis, enabling an erection. In neonates, it maintains ductus arteriosus patency, ensuring proper oxygenation before corrective surgery.

Benefits of Alprostadil

• Effective treatment for ED with fast onset of action
• Useful alternative when oral ED medications are ineffective
• Improves blood flow in vascular disorders
• Supports critical circulation in neonates with heart defects

How to Take Alprostadil

Alprostadil is available as an injection or a urethral suppository for erectile dysfunction. It should be administered under medical supervision initially to ensure correct usage. For neonates, it is administered intravenously by healthcare professionals in a hospital setting. Dosage and frequency depend on the condition and the patient's response to treatment.

Type of Dosage Available

• Penile injection (intracavernosal)
• Urethral suppository
• Intravenous injection (for infants)

Side Effects of Alprostadil

• Penile pain or burning sensation
• Prolonged erection (priapism)
• Redness, swelling at injection site
• Dizziness or low blood pressure
• In infants, fever or apnea (rare)

Safety Advice

• Use only under doctor’s guidance, especially with other ED medications
• Do not exceed recommended dose or frequency
• Avoid in patients with penile implants or anatomical deformation
• Seek medical help if erection lasts more than 4 hours
• Keep out of reach of children and store as per instructions

Frequently Asked Questions (FAQs)

Q. What is Alprostadil used for?
A. Alprostadil is used for erectile dysfunction and to improve blood flow in specific medical conditions.

Q. How is Alprostadil administered?
A. It is given either as a penile injection, urethral suppository, or IV infusion (in neonates).

Q. Can I use Alprostadil at home?
A. Yes, but only after proper instruction from a doctor for self-administration.

Q. How fast does Alprostadil work?
A. It typically works within 5 to 20 minutes when used for erectile dysfunction.

Q. What if I get an erection that won’t go away?
A. If an erection lasts more than 4 hours, seek immediate medical attention.