Dapagliflozin

Dapagliflozin is an oral medicine used to manage type 2 diabetes, heart failure, and chronic kidney disease (CKD). It works by blocking the chemical action responsible for glucose reabsorption from the kidney and for inhibiting its excretion. This action removes excess glucose from urine and helps control blood sugar levels. Beyond glucose control, dapagliflozin offers heart and kidney protection, reducing risks of cardiovascular events and disease progression. It is prescribed as a single agent or in combination with other medicines for patients needing long-term metabolic and organ support.

Uses of Dapagliflozin

• Manage Type-2 Diabetes: Treats type-2 diabetes by lowering blood glucose levels by eliminating glucose through urine. It helps lower blood sugar, aids weight loss, lowers blood pressure, and can protect the heart and kidneys.
• Reduces Risk of Heart Failure: Reduce the risk of heart failure. By lowering fluid overload and improving the heart's function, it provides strong heart protection and improves long-term outcomes for those at risk.
• Protects the Kidneys: Slows down chronic kidney disease by protecting the kidneys' ability to filter. It helps prevent further damage and maintains kidney function, especially in people with diabetes or kidney issues.
• Controls Weight: Control weight by getting rid of excess sugar and calories. This action supports gradual weight loss and is helpful for people who are overweight or have diabetes and are seeking better metabolic health.
• Lowers Blood Pressure: Decreases both high and low blood pressure. It works without electrolyte disturbances, making it helpful for controlling pressure, especially in people who also have sugar problems or heart issues.

How Dapagliflozin Works

Dapagliflozin works by inhibiting the SGLT2 protein in the kidneys, which prevents glucose reabsorption and promotes its excretion through urine. This helps lower blood sugar levels and supports overall metabolic health.

Benefits of Dapagliflozin

• Effectively lowers blood sugar levels
• Reduces the risk of heart failure
• Helps with weight loss in diabetic patients
• Protects kidney function

How to Take Dapagliflozin

Dapagliflozin should be taken as prescribed by a doctor. It is usually taken once daily, with or without food. Swallow the tablet whole with water. Do not crush or chew the tablet. Consistency in timing improves effectiveness.

Types of Dosage Available

• Dapagliflozin 5 mg Tablet
• Dapagliflozin 10 mg Tablet

Side Effects of Dapagliflozin

• Increased urination
• Urinary tract infections
• Low blood pressure
• Genital yeast infections
• Dehydration

Safety Advice

• Not recommended for type 1 diabetes
• Avoid if you have severe kidney disease
• Drink plenty of fluids to prevent dehydration
• Monitor blood sugar levels regularly
• Inform your doctor if you are pregnant or breastfeeding

Frequently Asked Questions

Q: Can Dapagliflozin be used for type 1 diabetes?
A: No, it is only approved for type 2 diabetes management.

Q: How long does Dapagliflozin take to show results?
A: It starts lowering blood sugar within a few days, but full effects may take weeks.

Q: Can Dapagliflozin cause dehydration?
A: Yes, it may cause dehydration due to increased urination. Drink enough water daily.

Q: Is Dapagliflozin safe for kidney patients?
A: It helps protect kidney function but is not recommended for advanced kidney disease.

Q: Can Dapagliflozin help with weight loss?
A: Yes, it may aid weight loss by reducing excess glucose and calories in urine.