Dapoxetine

Dapoxetine is a prescription medicine primarily used in the treatment of premature ejaculation in adult men. It may also be prescribed for conditions such as anxiety disorders. Dapoxetine belongs to the class of serotonin reuptake inhibitors. It works by blocking the reabsorption of serotonin in the brain, which helps in delaying the premature ejaculation. Dapoxetine may have some side effects such as insomnia, fatigue, dizziness, headache and nausea.

Uses of Dapoxetine

Dapoxetine is used in the treatment of premature ejaculation and the management of anxiety disorders.

• Treatment of premature ejaculation: Dapoxetine is used to treat premature ejaculation, as it blocks the serotonin reabsorption and delays ejaculation.

• Management of anxiety: Dapoxetine can be used to manage anxiety only when prescribed by a doctor, as it helps maintain serotonin levels in the brain.

How Dapoxetine Works

Dapoxetine works by blocking the serotonin reabsorption, leading to increased serotonin levels in the brain, which delays the ejaculation reflex. This helps men improve their control over ejaculation and prolongs the time before ejaculation during sexual activity.

Benefits of Dapoxetine

• Provides effective treatment for premature ejaculation
• Help improves sexual performance and confidence
• May help in increasing the duration of sexual activity
• Minimises stress and anxiety related to premature ejaculation

How to Take Dapoxetine

Dapoxetine should be taken 1-3 hours before anticipated sexual activity. Swallow the tablet with a full glass of water, with or without food. Do not take more than one dose within 24 hours. Follow your doctor`'s advice regarding dosage and duration.

Types of Dosage Available

Dapoxetine is available in 30 mg and 60 mg tablet strengths. Your doctor will prescribe the appropriate dose based on your condition, response to treatment, and overall health.

Side Effects of Dapoxetine

Dapoxetine may cause side effects, including nausea, dizziness, headache, diarrhoea, insomnia, and fatigue. In rare cases, it may lead to fainting or mood changes. If you experience severe or persistent side effects, contact your doctor immediately. Side effects of dapoxetine are given below:

• Nausea
• Dizziness
• Headache
• Diarrhoea
• Insomnia
• Fatigue
• Rarely, fainting or mood changes

Drug Interactions

Dapoxetine may interact with other medicines, which affects its safety and increases the risk of adverse effects.

• MAOIs and other serotonin-affecting medicines: Taking dapoxetine with other serotonin-affecting medicines such as MAOIs, SSRIs can cause accumulation of serotonin in the brain. This process may result in life-threatening confusion, tremors, muscle spasms, and rhythmic muscle twitching. 
• Liver enzyme inhibitors: Medicines that inhibit liver enzymes may increase the levels of dapoxetine in blood, resulting in seizures, tremors, low blood pressure, and increased heart rate.  
• Blood thinners: Taking dapoxetine with blood thinners such as aspirin or warfarin may increase the risk of unusual bleeding or bruising. 
• Heart rhythm and erectile dysfunction medicines: Consuming dapoxetine with ED medicines or heart rate medicines may cause a sudden sharp drop in blood pressure and lead to fainting.
• Anti-psychotic drugs: Dapoxetine can inhibit the metabolism of thioridazine, leading to high levels that increase the risk of dangerous heart rhythm problems.

Food Interactions

The choice of food and beverages while taking dapoxetine may also affect its absorption and effectiveness.

• Grapefruit juice: It inhibits liver enzymes, which affects the processing of dapoxetine in the body and results in high levels of dapoxetine in the blood. 
• Alcohol: Taking dapoxetine while consuming alcohol may increase the risk of dizziness, impaired motor skills and serious fainting episodes.
• St John’s wort: Taking St John’s wort while consuming dapoxetine may cause serotonin syndrome, making it life-threatening.

Safety Advice

• Do not use dapoxetine if you have a history of heart problems or severe liver disease.
• Avoid alcohol, as it can increase dizziness and other side effects.
• Not recommended for men under 18 or over 65 years of age.
• Inform your doctor about any ongoing medications or health conditions.
• Do not take Dapoxetine with recreational drugs or other antidepressants.