Human Coagulation Factor VIII

Human Coagulation Factor VIII is a vital blood-clotting protein used in the treatment and prevention of bleeding episodes in individuals with hemophilia A, a genetic disorder where Factor VIII is deficient or absent. It is either derived from human plasma or produced using recombinant DNA technology. This medication helps control bleeding during surgeries, injuries, or spontaneous bleeding episodes. It is administered intravenously and must be used under medical supervision.

Uses of Human Coagulation Factor VIII

• Treatment of bleeding episodes in hemophilia A patients
• Prevention of bleeding during surgical procedures
• Routine prophylaxis to reduce the frequency of bleeding
• Short-term control of bleeding in emergencies

How Human Coagulation Factor VIII Works

Human Coagulation Factor VIII works by temporarily raising the levels of clotting Factor VIII in the blood, helping the blood to clot properly and preventing or controlling bleeding in hemophilia A patients.

Benefits of Human Coagulation Factor VIII

• Controls and prevents bleeding effectively in hemophilia A
• Essential for safe surgical procedures in affected individuals
• Reduces long-term joint damage by preventing bleeds
• Improves quality of life through routine prophylaxis
• Available in both plasma-derived and recombinant forms

How to Take Human Coagulation Factor VIII

This medicine is given by slow injection into a vein, usually in a clinical setting. The dosage and frequency depend on the severity of Factor VIII deficiency, the patient’s weight, and the type of treatment (on-demand or preventive). Always follow the healthcare provider's instructions closely.

Type of Dosage Available

• Injection (intravenous powder for reconstitution)
• Prefilled syringes (in some formulations)

Side Effects of Human Coagulation Factor VIII

• Fever
• Headache
• Nausea
• Chills
• Injection site reactions
• Allergic reactions (rare but serious)
• Development of inhibitors (antibodies against Factor VIII)

Safety Advice

• Use only under specialist supervision
• Inform your doctor about any previous allergic reactions
• Monitor for the development of inhibitors during prolonged use
• Store in a refrigerator or as advised on the label
• Do not shake the vial after reconstitution
• Keep away from children

Frequently Asked Questions (FAQs)

Q: What is Human Coagulation Factor VIII used for?
A: It is used to treat and prevent bleeding in patients with hemophilia A, especially during injuries or surgeries.

Q: How is Human Coagulation Factor VIII administered?
A: It is given through a vein by a healthcare professional. Some patients are trained to self-administer at home.

Q: Can Human Coagulation Factor VIII be used for other bleeding disorders?
A: No, it is specifically for hemophilia A and should not be used in other conditions unless prescribed.

Q: Are there any serious risks with long-term use?
A: Some patients may develop inhibitors (antibodies) that reduce the drug’s effectiveness. Regular monitoring is needed.

Q: Is Human Coagulation Factor VIII safe during pregnancy?
A: It should be used during pregnancy only if clearly needed and prescribed by a healthcare provider.