Nateglinide + Metformin

Introduction

Nateglinide + Metformin is a combination medicine commonly prescribed to manage type 2 diabetes mellitus. Nateglinide belongs to a class of drugs called meglitinides that help stimulate insulin release, while Metformin is a biguanide that improves insulin sensitivity and decreases glucose production in the liver. Together, they work effectively to control blood sugar levels, especially after meals. This composition is typically recommended when lifestyle changes and single-drug therapy are not sufficient to control blood sugar. It is available in oral tablet form and should be taken as per the doctor's prescription.

Uses of Nateglinide + Metformin

• Management of type 2 diabetes mellitus
• Helps control postprandial (after meal) blood glucose levels
• Reduces insulin resistance
• Prevents diabetes-related complications

How Nateglinide + Metformin works

Nateglinide stimulates the pancreas to release insulin in response to meals, while Metformin decreases glucose production in the liver and improves insulin sensitivity. This dual action helps in better glycemic control by reducing both fasting and postprandial blood sugar levels.

Benefits of Nateglinide + Metformin

• Effective control of blood sugar levels
• Targets both fasting and post-meal glucose
• Reduces risk of long-term diabetes complications
• Improves insulin response and sensitivity
• Supports overall metabolic health

How to take Nateglinide + Metformin

This medication should be taken orally with meals to reduce gastrointestinal side effects and enhance its effectiveness. The dosage is based on your medical condition and response to treatment. Follow your doctor's instructions carefully and do not skip doses. Regular monitoring of blood sugar levels is recommended.

Type of Dosage Available

• Oral tablets
• Extended-release tablets (in some brands)

Side effects of Nateglinide + Metformin

• Hypoglycemia (low blood sugar)
• Nausea and vomiting
• Diarrhea
• Abdominal pain
• Loss of appetite
• Lactic acidosis (rare but serious)

Safety advice

• Do not skip meals while taking this medication to avoid hypoglycemia
• Avoid alcohol as it increases the risk of lactic acidosis
• Inform your doctor if you have kidney or liver issues
• Use with caution during pregnancy or breastfeeding
• Regularly monitor blood sugar levels

Frequently Asked Questions (FAQs)

Q: What is Nateglinide + Metformin used for?
A: It is used to control blood sugar levels in patients with type 2 diabetes mellitus.

Q: Can I take Nateglinide + Metformin with food?
A: Yes, it should be taken with meals to minimize stomach upset and prevent low blood sugar.

Q: What should I do if I miss a dose?
A: Take the missed dose with your next meal unless it's almost time for your next dose. Do not double the dose.

Q: Is it safe to use during pregnancy?
A: Use only if prescribed by your doctor after assessing the benefits and risks.

Q: Can this combination cause low blood sugar?
A: Yes, especially if you skip meals or exercise more than usual. Monitor your levels regularly.