Pegaptanib

Introduction

Pegaptanib is a prescription medication used to treat age-related macular degeneration (AMD), specifically the "wet" form of the disease. It is classified as an anti-VEGF (vascular endothelial growth factor) agent. Pegaptanib works by blocking a protein in the eye that leads to abnormal blood vessel growth and leakage, which can damage vision. It is administered as an intravitreal injection (into the eye) by a healthcare professional. Pegaptanib helps slow vision loss and in some cases may improve vision in patients with neovascular AMD.

Uses of Pegaptanib

• Wet age-related macular degeneration (wet AMD)
• Prevention of vision loss in AMD patients
• Reduction of abnormal blood vessel growth in the eye

How Pegaptanib Works

Pegaptanib binds to and inhibits vascular endothelial growth factor (VEGF165), a protein responsible for abnormal blood vessel formation in the retina. By blocking this protein, Pegaptanib reduces leakage, bleeding, and swelling in the eye, helping to preserve and potentially improve vision in patients with wet AMD.

Benefits of Pegaptanib

• Slows progression of vision loss in wet AMD
• Reduces abnormal blood vessel growth
• Minimizes bleeding and fluid leakage in the retina
• Helps maintain or improve visual acuity
• Administered directly into the eye for targeted action

How to Take Pegaptanib

Pegaptanib is administered by an ophthalmologist as an intravitreal injection (into the eye) once every six weeks. The eye is numbed before the procedure, and the injection is given under sterile conditions. Do not self-administer this medication. Follow your doctor’s instructions and attend all scheduled appointments.

Type of Dosage Available

• Intravitreal injection (administered by a doctor)
• Available in pre-filled syringes or vials for clinical use

Side Effects of Pegaptanib

• Eye pain or discomfort
• Increased eye pressure
• Inflammation inside the eye (endophthalmitis)
• Blurred vision
• Floaters or visual disturbances
• Eye redness or discharge
• Serious allergic reactions (rare)

Safety Advice

• For use only under supervision of an eye specialist
• Inform your doctor of any existing eye infections or conditions
• Avoid rubbing or touching your eyes after injection
• Report any severe pain, redness, or vision changes immediately
• Use caution if pregnant or breastfeeding – consult your doctor
• Follow hygiene and care instructions after the injection

Frequently Asked Questions (FAQs)

Q: What is Pegaptanib used for?
A: Pegaptanib is used to treat wet age-related macular degeneration by slowing abnormal blood vessel growth in the retina.

Q: How is Pegaptanib administered?
A: It is given as an intravitreal injection directly into the eye by a healthcare professional, usually every six weeks.

Q: Can Pegaptanib restore lost vision?
A: While Pegaptanib may help improve vision in some patients, its main benefit is slowing further vision loss.

Q: Is Pegaptanib safe for long-term use?
A: Yes, it is generally considered safe when administered as prescribed, though regular monitoring is required.

Q: What should I do after receiving a Pegaptanib injection?
A: Avoid rubbing your eyes, watch for any signs of infection, and follow your doctor’s aftercare advice.