Phenindione

Introduction

Phenindione is an anticoagulant medication used to prevent and treat blood clots in various medical conditions. It works similarly to warfarin and is prescribed in cases where blood thinning is necessary to avoid complications such as stroke or deep vein thrombosis (DVT). Though it is less commonly used today due to the availability of newer anticoagulants, it may still be used in specific clinical situations. Phenindione must be taken under strict medical supervision due to its narrow therapeutic index and potential interactions.

Uses of Phenindione

• Prevention of deep vein thrombosis (DVT)
• Prevention of pulmonary embolism
• Prevention of stroke in patients with atrial fibrillation
• Treatment of existing blood clots

How Phenindione works

Phenindione works by inhibiting the synthesis of vitamin K-dependent clotting factors in the liver. This action reduces the blood’s ability to clot, helping to prevent the formation of harmful blood clots in the vessels, especially in individuals at high risk.

Benefits of Phenindione

• Effective in preventing serious blood clot complications
• Can be used as an alternative for patients allergic to warfarin
• Reduces the risk of stroke in atrial fibrillation patients
• Helpful in long-term anticoagulation therapy

How to take Phenindione

Phenindione should be taken exactly as prescribed by your doctor. The dosage may vary based on your blood test results (INR levels) and individual health conditions. It is usually taken once a day at the same time daily. Regular blood monitoring is necessary to adjust the dose and avoid bleeding complications.

Type of Dosage Available

• Phenindione 25mg Tablet
• Phenindione 50mg Tablet

Side effects of Phenindione

• Bleeding gums
• Nosebleeds
• Blood in urine or stools
• Bruising easily
• Rash or allergic reaction
• Liver function disturbances (rare)

Safety Advice

• Avoid taking with other blood thinners unless advised
• Inform your doctor about all other medications you take
• Regular INR monitoring is essential
• Not recommended during pregnancy or breastfeeding unless prescribed
• Use with caution in patients with liver or kidney disease
• Avoid alcohol consumption as it may increase bleeding risk

Frequently Asked Questions (FAQs)

Q1. What is Phenindione used for?

A1. Phenindione is used to prevent and treat blood clots, including deep vein thrombosis, pulmonary embolism, and to reduce stroke risk in atrial fibrillation patients.

Q2. Is Phenindione safe for long-term use?

A2. Yes, but only under medical supervision with regular monitoring of INR levels to ensure safe blood thinning and avoid complications.

Q3. Can I take Phenindione during pregnancy?

A3. It is generally not recommended during pregnancy. Consult your doctor for safer alternatives if you are pregnant or planning to conceive.

Q4. What should I do if I miss a dose?

A4. Take the missed dose as soon as you remember. If it’s close to the next dose, skip the missed dose. Do not double the dose.

Q5. Can I stop taking Phenindione suddenly?

A5. No, do not stop taking Phenindione without consulting your doctor, as stopping suddenly can increase the risk of clot formation.