Saxagliptin + Metformin

Introduction

Saxagliptin + Metformin is a combination medicine used to manage Type 2 Diabetes Mellitus. It helps control blood sugar levels in adults when diet and exercise alone are not sufficient. Saxagliptin is a DPP-4 inhibitor that helps increase insulin release, while Metformin reduces glucose production in the liver and improves insulin sensitivity. This combination provides better blood sugar control, lowers the risk of diabetes-related complications, and is commonly prescribed for long-term management of the condition.

Uses of Saxagliptin + Metformin

• Management of Type 2 Diabetes Mellitus
• Helps reduce HbA1c (average blood sugar levels)
• Used in adults when single drug therapy is not effective

How Saxagliptin + Metformin works

Saxagliptin works by inhibiting the enzyme DPP-4, which increases the release of insulin and decreases glucagon levels. Metformin works by lowering glucose production in the liver, delaying sugar absorption in the intestines, and improving the body's response to insulin. Together, they help in effective control of blood sugar levels.

Benefits of Saxagliptin + Metformin

• Effective dual-action control of blood sugar levels
• Reduces the risk of diabetes complications
• Helps in weight management in some patients
• Improves insulin sensitivity and glucose utilization
• Suitable for long-term use with proper monitoring

How to take Saxagliptin + Metformin

Take Saxagliptin + Metformin as prescribed by your doctor, usually once or twice a day with meals to reduce stomach upset. Swallow the tablet whole with water. Do not crush or chew it. Your doctor may adjust the dose based on your blood sugar levels and response to the medication.

Type of Dosage Available

• Tablets (Immediate-release)
• Tablets (Extended-release)
• Various strength combinations like 2.5mg/500mg, 5mg/500mg, etc.

Side effects of Saxagliptin + Metformin

• Nausea and vomiting
• Diarrhea
• Headache
• Low blood sugar (hypoglycemia)
• Stomach discomfort
• Upper respiratory tract infection
• Lactic acidosis (rare but serious)
• Pancreatitis (rare)

Safety Advice

• Consult your doctor if you have kidney or liver issues
• Do not consume alcohol while on this medication
• Inform your doctor if you are pregnant or breastfeeding
• Regularly monitor your blood sugar levels
• Use caution in elderly patients due to risk of lactic acidosis

Frequently Asked Questions (FAQs)

Q. Can I take Saxagliptin + Metformin with other diabetes medicines?

Yes, but only under medical supervision. Your doctor may adjust your dose to avoid low blood sugar.

Q. What should I do if I miss a dose?

Take the missed dose as soon as you remember. If it's close to the next dose, skip the missed one. Do not double the dose.

Q. Can Saxagliptin + Metformin cause weight loss?

Some people may experience mild weight loss, but it is not the primary effect of this medicine.

Q. Is Saxagliptin + Metformin safe for long-term use?

Yes, it is generally safe when used as prescribed and with regular monitoring of blood sugar and kidney function.

Q. Can I drink alcohol while taking this medicine?

No, alcohol may increase the risk of lactic acidosis and low blood sugar. Avoid drinking alcohol during treatment.