Dapagliflozin + Metformin + Sitagliptin

Dapagliflozin + Metformin + Sitagliptin is a triple-combination medicine used to manage type 2 diabetes in adults. It works in three different ways to help keep blood sugar levels under control when diet and exercise alone are not enough. Metformin helps reduce sugar production in the liver and improves the body’s response to insulin. Sitagliptin increases insulin release after meals by supporting natural hormones that control blood sugar. Dapagliflozin helps remove excess sugar from the body through urine, offering an additional layer of control.

This powerful combination is often prescribed when a single or dual therapy does not give desired results. By targeting blood sugar from multiple angles, it helps achieve better glycemic control throughout the day. When taken as advised by a doctor, along with a healthy lifestyle, this medicine can support long-term diabetes management and overall well-being.

Uses of Dapagliflozin + Metformin + Sitagliptin

• Management of type 2 diabetes mellitus
• Improves glycemic control in adults inadequately controlled on dual therapy
• Reduces the risk of diabetes-related complications
• Supports weight management in diabetic patients

How Dapagliflozin + Metformin + Sitagliptin Works

Metformin decreases glucose production in the liver and increases insulin sensitivity. Dapagliflozin helps eliminate excess glucose via the urine by blocking SGLT2. Sitagliptin increases insulin release and decreases glucagon levels by inhibiting DPP-4. Together, they provide a triple mechanism to reduce blood sugar effectively.

Benefits of Dapagliflozin + Metformin + Sitagliptin

• Enhanced blood sugar control
• Low risk of hypoglycemia
• Supports weight loss or maintenance
• Once or twice-daily convenient dosing
• Protective effects on the heart and kidneys (Dapagliflozin)

How to Take Dapagliflozin + Metformin + Sitagliptin

This combination is usually taken orally with food to reduce stomach upset. The dosage and frequency are determined by the doctor based on your current blood sugar levels and response to treatment. Never take more than the prescribed dose.

Type of Dosage Available

• Oral tablets (various strengths)

Side Effects of Dapagliflozin + Metformin + Sitagliptin

• Nausea, vomiting, or diarrhea (Metformin-related)
• Urinary tract infections (Dapagliflozin-related)
• Headache or sore throat
• Low blood sugar (rare, usually with other antidiabetics)
• Genital infections (Dapagliflozin-related)
• Vitamin B12 deficiency (long-term Metformin use)

Safety Advice

• Monitor kidney function regularly
• Inform your doctor of any heart or liver conditions
• Stay hydrated to avoid dehydration or low blood pressure
• Not recommended during pregnancy or breastfeeding unless prescribed
• Avoid alcohol to reduce risk of lactic acidosis
• Use cautiously in elderly patients

Frequently Asked Questions (FAQs)

Q1. What is the main use of Dapagliflozin + Metformin + Sitagliptin?
It is used to control high blood sugar levels in adults with type 2 diabetes.

Q2. Can I stop taking this medicine if I feel better?
No, diabetes is a chronic condition. Continue taking it as prescribed even if your symptoms improve.

Q3. Does this combination cause low blood sugar?
It has a low risk of hypoglycemia unless combined with insulin or sulfonylureas.

Q4. Can this combination be used in patients with kidney problems?
It should be used cautiously, and kidney function should be monitored regularly. Dose adjustments may be necessary.

Q5. Is this medication helpful in weight loss?
Yes, Dapagliflozin may support weight loss in diabetic patients.