Naxdom 500 Tablet

Naxdom 500 Tablet is a prescription medicine containing Naproxen 500 mg and Domperidone 10 mg. It is mainly used in the treatment of acute migraine attacks, especially when migraine headache is accompanied by nausea or vomiting. Naproxen helps to reduce migraine-related pain, while Domperidone helps to control nausea and vomiting.

Naxdom 500 tablet uses

Naxdom 500 Tablet is used to manage an ongoing migraine attack and is not generally intended for the routine prevention of migraines. 

• It may help to reduce the intensity of migraine and associated pain.
• Domperidone may help control nausea and vomiting that can occur during a migraine attack.

Benefits

Naxdom 500 mg Tablet helps to manage both migraine pain and associated nausea or vomiting.

• May reduce the severity of migraine headaches.
• Helps manage pain associated with an acute migraine attack.
• May reduce migraine-related nausea and vomiting.
• Combines pain relief and antiemetic action in one tablet.

How to Take Naxdom 500 Tablet

Take the Naxdom 500 Tablet exactly as prescribed by your doctor.

• Swallow the tablet whole with water.
• Do not crush, chew, or break it unless your doctor advises otherwise.
• Taking naproxen with food or milk may help reduce stomach upset.
• Do not take more than the prescribed dose or use it more frequently than recommended.
• Do not change your dose without medical advice.
• If an overdose is suspected, seek immediate medical attention or contact your doctor or the nearest emergency medical service.
• If you forget a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose.

How Naxdom 500 Tablet Works

Naxdom 500 Tablet contains two medicines that work in different ways. Together, these ingredients help manage both (migraine) and associated gastrointestinal symptoms:

• Naproxen → NSAID → Reduces prostaglandin production → Helps reduce pain and inflammation. Prostaglandins are chemicals involved in pain and inflammation.
• Domperidone → Antiemetic and prokinetic medicine → Improves stomach movement and acts on pathways involved in nausea and vomiting → Helps control nausea and vomiting related to migraine.

Side Effects

Naxdom 500 Tablet may cause side effects, although not everyone experiences them. Common or possible Naxdom 500 tablet side effects may include:

• Nausea or vomiting
• Stomach pain or indigestion
• Heartburn
• Diarrhoea or constipation
• Dry mouth
• Dizziness
• Drowsiness or tiredness

Some mild side effects may improve as the medicine is cleared from the body. Contact your doctor if any side effect persists, worsens, or becomes troublesome.

Seek urgent medical attention if you develop symptoms such as:

• Vomiting blood or passing black, tarry stools, which may indicate stomach or intestinal bleeding
• Severe allergic symptoms, such as swelling of the face or throat or difficulty breathing
• Severe chest pain or sudden weakness
• Severe or persistent abdominal pain
• A fast, irregular, or unusual heartbeat

Safety Advice

Follow your doctor's advice while taking Naxdom 500 Tablet. Keep the following precautions in mind:

• Alcohol: Avoid or limit alcohol, as it may increase the risk of stomach irritation and bleeding.
• Pregnancy: Use only if prescribed by your doctor, as naproxen may pose risks during pregnancy.
• Breastfeeding: Consult your doctor before use, as the ingredients may pass into breast milk.
• Driving: Avoid driving or operating machinery if you experience dizziness or drowsiness.
• Kidney: Use with caution and under medical supervision if you have kidney problems.
• Liver: Inform your doctor if you have liver problems, as medical supervision may be required.

Interactions

Naxdom 500 Tablet can interact with certain foods, beverages, and medicines. Tell your doctor or pharmacist about all prescription medicines, over-the-counter medicines, and supplements you use.

Food Interactions

No specific food interaction is generally established for this combination. However, taking naproxen with food or milk may help reduce stomach upset.

Drug Interactions

• Other NSAIDs or pain medicines: Taking naproxen with other NSAIDs may increase the risk of stomach ulcers, bleeding, and kidney-related side effects.
• Blood thinners and antiplatelet medicines: Medicines that reduce blood clotting may increase the risk of bleeding when used with naproxen.
• Diuretics and certain blood pressure medicines: Naproxen may reduce the effectiveness of some diuretics or antihypertensive medicines and may increase the risk of kidney problems in susceptible individuals.
• Digoxin: Naproxen may increase digoxin levels, which can increase the risk of digoxin-related adverse effects.
• Medicines affecting heart rhythm: Domperidone may not be suitable with certain medicines that affect heart rhythm or increase domperidone levels, as this may increase the risk of serious heart rhythm problems.
• Methotrexate: Naproxen may increase methotrexate exposure and the risk of toxicity.
• SSRIs/SNRIs: May increase the risk of gastrointestinal bleeding when used with naproxen.
• QT-prolonging medicines: Domperidone should not be combined with medicines that prolong the QT interval because of an increased risk of serious heart rhythm problems.
• Potent CYP3A4 inhibitors: Medicines such as ketoconazole, itraconazole, erythromycin and clarithromycin can increase domperidone levels and the risk of QT prolongation and cardiac arrhythmias.
• Antacids and antisecretory medicines: May reduce the oral absorption of domperidone if taken at the same time; they should generally be taken separately.

Always inform your doctor or pharmacist about your current medicines before taking Naxdom 500 Tablet.

Frequently Asked Questions (FAQs)

Q: What is Naxdom 500 Tablet used for?
A: Naxdom 500 Tablet is used to treat acute migraine headaches and associated symptoms like nausea and vomiting.

Q: What are the benefits of Naxdom 500 Tablet?
A: It provides fast pain relief, reduces inflammation, and prevents migraine-related nausea, improving comfort during an attack.

Q: What are the side effects of Naxdom 500 Tablet?
A: Naxdom 500 Tablet Common side effects include nausea, stomach pain, dizziness, and dry mouth. Rarely, it may cause stomach bleeding or severe allergic reactions.

Q: What should I do in case of an overdose?
A: An overdose can cause extreme dizziness, stomach bleeding, breathing problems, or heart issues. Seek emergency medical care immediately.

Q: Is Naxdom 500 safe during pregnancy or breastfeeding?
A: It is not recommended during pregnancy, especially in the third trimester, and should be used cautiously during breastfeeding only if prescribed by a doctor.

Q: Which is the most affordable substitute or alternative of Naxdom 500 Tablet available in India?
A: Naprozee DM 500 is a more affordable alternative to Naxdom 500 Tablet. Both of these medicines contain Naproxen (500mg) + Domperidone (10mg) and are equally effective.

Q: How quickly does Naxdom 500 Tablet work?
A: Naxdom 500 may start working within 30–60 minutes, but the time and level of relief can vary depending on the individual and migraine severity.

Q: Is Naxdom 500 Tablet safe for the kidneys?
A: Naxdom 500 may affect kidney function, especially with frequent use or kidney disease. Use it only as prescribed by your doctor.